{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:09:34Z","timestamp":1790604574785,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":270,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017534","name":"Inner Mongolia Medical University","doi-asserted-by":"publisher","award":["2023NYFYTS004"],"award-info":[{"award-number":["2023NYFYTS004"]}],"id":[{"id":"10.13039\/100017534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CYP2C19 genotype can influence clopidogrel response, but the relationship between routine genotyping, real\u2010world P2Y12 inhibitor prescribing, and clinical outcomes remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterize P2Y12 inhibitor prescription patterns before and after routine CYP2C19 genotyping and to describe ischemic and bleeding outcomes in a retrospective real\u2010world cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective study included 364 adults with coronary heart disease who underwent percutaneous coronary intervention (PCI) from January to December 2023. During the study period, CYP2C19 genotyping was routinely performed as part of the hospital\u2019s antiplatelet management policy, and all 364 participants were genotyped. Prescription patterns before and after genotype results were compared; clinical outcome analyses were restricted to the 271 patients with complete linked postdischarge medication and outcome data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Before genotyping, 273\/364 patients (75.0%) received ticagrelor, and 91\/364 (25.0%) received clopidogrel; after genotype results, 279\/364 (76.6%) received clopidogrel, and 85\/364 (23.4%) received ticagrelor. From the reported adjustment counts, 258 patients switched from ticagrelor to clopidogrel, 70 switched from clopidogrel to ticagrelor, and 36 remained on the same agent (exact McNemar\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). CYP2C19 genotypes were \u22171\/\u22171 in 132 (36.3%; normal metabolizer), \u22171\/\u22172 or \u22171\/\u22173 in 179 (49.2%; intermediate metabolizer), and two loss\u2010of\u2010function alleles in 53 (14.5%; poor metabolizer). In the 271\u2010patient outcome subset, event counts were low, and treatment strata were highly imbalanced. Fisher exact comparisons were therefore considered exploratory, and no causal effect of genotyping or drug selection was inferred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Routine CYP2C19 genotyping was associated with a substantial change in P2Y12 inhibitor prescribing in this single\u2010center cohort. Because treatment was physician\u2010directed and outcome data were sparse and incomplete for the full cohort, the clinical event comparisons should be interpreted as exploratory rather than evidence that genotype\u2010guided therapy reduced bleeding or ischemic events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crp\/6267485","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:29:56Z","timestamp":1790602196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Routine CYP2C19 Genotyping, Antiplatelet Prescription Changes, and Clinical Outcomes After PCI in Chinese Patients With Coronary Heart Disease: A Single\u2010Center Retrospective Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6404-0798","authenticated-orcid":false,"given":"Dan","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9482-1223","authenticated-orcid":false,"given":"Hong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"Coronary Heart Disease: Epidemiology and Prevention","author":"Danaei G.","year":"2020"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100718"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2021.02.009"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0644-7"},{"key":"e_1_2_10_6_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.26599\/1671-5411.2023.06.001","article-title":"Report on Cardiovascular Health and Diseases in China 2021: An Updated Summary","volume":"20","author":"Sheng-Shou H. U.","year":"2023","journal-title":"Journal of Geriatric Cardiology"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI135959"},{"key":"e_1_2_10_8_2","first-page":"1","article-title":"Coronary Artery Disease: From Mechanism to Clinical Practice","author":"Shao C. I","year":"2020","journal-title":"Coronary Artery Disease: Therapeutics and Drug Discovery"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15221"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1758821"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1499-3"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.019184"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12921"},{"key":"e_1_2_10_14_2","first-page":"103","article-title":"Antithrombotic Therapy: Prevention and Treatment of Atherosclerosis and Atherothrombosis","author":"Olie R. H.","year":"2020","journal-title":"Prevention and Treatment of Atherosclerosis: Improving State-of-the-Art Management and Search for Novel Targets"},{"key":"e_1_2_10_15_2","article-title":"Coronary Heart Disease (CHD) in Elderly Patients: Which Drug to Choose, Ticagrelor and Clopidogrel? A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"8","author":"Akkaif M. A. D.","year":"2021","journal-title":"Journal of Cardiovascular Development and Disease"},{"key":"e_1_2_10_16_2","volume-title":"New Perspectives for Antiplatelet Therapy: The Evolution of P2Y12 Receptor Antagonists","author":"Silva P.","year":"2021"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-020-00864-4"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19158977"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac544.1231"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.532485"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1191\/135886398677811630"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.887748"},{"key":"e_1_2_10_23_2","article-title":"The Role of Genetic Polymorphism and Other Factors on Clopidogrel Resistance (CR) in an Asian Population With Coronary Heart Disease (CHD)","volume":"26","author":"Akkaif M. A. D.","year":"2021","journal-title":"Molecules"},{"key":"e_1_2_10_24_2","doi-asserted-by":"crossref","unstructured":"DogotM.et al. Influence of CYP2C19\u2217 2 Polymorphism on Clinical Outcomes in Moldova\u2019s Patients Treated With Clopidogrel After Percutaneous Coronary Intervention International Conference on Nanotechnologies and Biomedical Engineering 2023 Cham Switzerland Springer Nature Switzerland.","DOI":"10.1007\/978-3-031-42775-6_56"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.122.027466"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570161117666190524123225"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.120.050845"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413302"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2526"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12443"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907096"}],"container-title":["Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crp\/6267485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crp\/6267485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crp\/6267485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:30:00Z","timestamp":1790602200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crp\/6267485"}},"subtitle":[],"editor":[{"given":"Satabdi","family":"Datta Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crp\/6267485"],"URL":"https:\/\/doi.org\/10.1155\/crp\/6267485","archive":["Portico"],"relation":{},"ISSN":["2090-8016","2090-0597"],"issn-type":[{"value":"2090-8016","type":"print"},{"value":"2090-0597","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6267485"}}