{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:48:00Z","timestamp":1782193680328,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":172,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["25Y12800700"],"award-info":[{"award-number":["25Y12800700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20MC1920500"],"award-info":[{"award-number":["20MC1920500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074163"],"award-info":[{"award-number":["82074163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated whether electroacupuncture (EA) at Neiguan (PC6) acupoint alleviates adverse myocardial remodeling in post\u2013myocardial infarction (MI) heart failure (HF) by activating the vagus nerve\u2013mediated cholinergic pathway and its downstream \u03b17nAChR\u2010Akt\u2010HIF\u20101\u03b1\u2010VEGF signaling cascade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male Sprague Dawley (SD) rats were randomized into sham, MI model, and EA groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096 per group). MI was induced by ligation of the left anterior descending coronary artery. EA was applied at PC6 for 14\u2009days starting 1\u2009week after MI induction. Cardiac function and structure were evaluated using echocardiography and histological examination. The expression levels of choline acetyltransferase (ChAT), \u03b17\u2010nicotinic acetylcholine receptor (\u03b17nAChR), phosphorylated Akt (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010Akt), hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1), and vascular endothelial growth factor (VEGF) were analyzed by real\u2010time quantitative PCR, Western blotting, and immunohistochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EA intervention significantly attenuated pathological myocardial remodeling and improved cardiac function. Compared with the model group, EA treatment markedly enhanced cardiac function, increased contractility, reduced ventricular dilation, restored autonomic balance, and alleviated myocardial necrosis and fibrosis. Molecular studies revealed that EA treatment increased the expression of ChAT and \u03b17nAChR, elevated\n                      <jats:italic>p<\/jats:italic>\n                      \u2010Akt levels, and upregulated the expression of HIF\u20101\u03b1 and VEGF. These findings suggest the activation of the vagus nerve\u2013cholinergic signaling pathway and its downstream prosurvival and pro\u2010angiogenic pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EA attenuated maladaptive ventricular remodeling and improved cardiac performance. These effects were associated with modulation of autonomic function and engagement of the \u03b17nAChR\/Akt\/HIF\u20101\u03b1\/VEGF signaling axis, supporting a potential neuro\u2010immune\u2010angiogenic mechanism underlying EA\u2010mediated myocardial repair during the subacute post\u2010MI phase.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crp\/9919619","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:25:26Z","timestamp":1782192326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture Protects Against Post\u2010MI Heart Failure Through Autonomic Regulation and \u03b17nAChR Activation"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4806-8510","authenticated-orcid":false,"given":"Weiting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9508-947X","authenticated-orcid":false,"given":"Jiaojiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2124-9212","authenticated-orcid":false,"given":"Yueling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6408-6737","authenticated-orcid":false,"given":"Qiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5845-7228","authenticated-orcid":false,"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-644X","authenticated-orcid":false,"given":"Aijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-9871","authenticated-orcid":false,"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwae281"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.114.302589"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.3881\/j.issn.1000-503X.16150"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00063"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmccpl.2023.100044"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2024.01.017"},{"key":"e_1_2_13_7_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10741-005-6802-7","article-title":"Heart Failure Following Anterior Myocardial Infarction: an Indication for Ventricular Restoration, a Surgical Method to Reverse Post-infarction Remodeling","volume":"9","author":"The RESTORE Group","year":"2005","journal-title":"Heart Failure Reviews"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01660-9"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512298"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.525"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.072652"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-015-9668-7"},{"key":"e_1_2_13_13_2","article-title":"Electrical Vagus Nerve Stimulation for the Treatment of Chronic Heart Failure","author":"Sabbah H. N.","year":"2011","journal-title":"Cleveland Clinic Journal of Medicine"},{"key":"e_1_2_13_14_2","volume-title":"Nicotinic Acetylcholine Receptor a7 Subunit is an Essential Regulator of Inflammation","author":"Wang H.","year":"2003"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933671"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104622"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-020-3269-2"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.70076"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15291"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114600"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2019.0267"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph21101369"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2018.10.003"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-023-10377-4"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136002"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70595"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107391"},{"key":"e_1_2_13_28_2","article-title":"The Role of \u03b17-nAChR-mediated PI3K\/AKT Pathway in Lung Cancer Induced by Nicotine","author":"He Z.","year":"2024","journal-title":"Science of the Total Environment"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1492806"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.12659\/msm.914265"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.28"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)63598-5"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-025-10888-7"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1584"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.13703\/j.0255-2930.20201206-k0004"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.13702\/j.1000-0607.190942"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102521"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/09645284211009536"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107863"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8237681"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.13703\/j.0255-2930.20221111-k0004"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116743"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.18-510"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020722"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2023.09.007"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4504431"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.06.003"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113792"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.045"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00051"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.12659\/msm.912051"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-007-0639-2"}],"container-title":["Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crp\/9919619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crp\/9919619","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crp\/9919619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:25:31Z","timestamp":1782192331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crp\/9919619"}},"subtitle":[],"editor":[{"given":"Irfan","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crp\/9919619"],"URL":"https:\/\/doi.org\/10.1155\/crp\/9919619","archive":["Portico"],"relation":{},"ISSN":["2090-8016","2090-0597"],"issn-type":[{"value":"2090-8016","type":"print"},{"value":"2090-0597","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9919619"}}