{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:11:15Z","timestamp":1790640675999,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":102,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2412400"],"award-info":[{"award-number":["2023YFC2412400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve replacement (TAVR) has been established as an alternative to surgery for high\u2010risk aortic regurgitation (AR) patients. However, its applicability to low\u2010 and intermediate\u2010risk populations remains under investigation. This study evaluates the clinical outcomes, quality of care, and patient\u2010centered implications of TAVR versus surgical aortic valve replacement (SAVR) in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 2021 and 2024, clinical data were retrospectively analyzed from 70 AR patients at our center, including 37 who underwent TAVR and 33 who received SAVR with bioprosthetic valves. Baseline characteristics, perioperative metrics, and major clinical outcomes were assessed. International registry data (FRANCE\u2010TAVI and ALIGN\u2010AR) were utilized for external validity comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics were comparable between groups. TAVR was associated with shorter operation time (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001), reduced blood use (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and shorter hospital stays (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.021). No 30\u2010day mortality was observed in TAVR, whereas four deaths occurred in the SAVR group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.029). Conduction abnormalities differed, with complete left bundle branch block (CLBBB) more frequent in TAVR (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.025) and complete right bundle branch block (CRBBB) in SAVR (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.029). Despite its minimally invasive nature, ICU observation time remained similar (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.339) due to perioperative complications. Economic analysis suggests potential cost savings with TAVR in specific scenarios.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TAVR offers favorable short\u2010term outcomes for low\u2010 to intermediate\u2010risk AR patients, yet challenges in perioperative care require optimization. Long\u2010term studies and multicenter trials are needed to refine patient selection and postprocedural management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crp\/9978726","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:01:40Z","timestamp":1776088900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Efficacy and Outcomes of Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement in Low\u2010 to Intermediate\u2010Risk Aortic Regurgitation Patients: A Comprehensive Clinical Comparison"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6958-1580","authenticated-orcid":false,"given":"Xiaoxue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9646-1921","authenticated-orcid":false,"given":"Chenxi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-4010","authenticated-orcid":false,"given":"Shiliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-0469","authenticated-orcid":false,"given":"Cai","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.119.041080"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25975"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.05.044"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.03.004"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2019.04.012"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01422-0"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14832"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.08.049"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1091983"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-24-00339"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(23)02806-4"},{"key":"e_1_2_10_13_2","article-title":"TAVI in Younger Patients: Is It a Reliable Option?","volume":"13","author":"A Rocha De Almeida MCDS","year":"2024","journal-title":"European Heart Journal-Acute Cardiovascular Care"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12962-024-00531-6"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-023-01590-x"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.06.088"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2024.07.025"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2024.02.012"}],"container-title":["Cardiology Research and 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