{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:32:02Z","timestamp":1793255522917,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":191,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Methadone is a synthetic opioid used to treat pain and opioid dependence. Despite its benefits, accidental ingestion of methadone in pediatric patients can lead to significant morbidity and mortality. Documented findings of acute toxicity secondary to methadone ingestion in children include leukoencephalopathy and cerebellitis. There is limited research into treatment and factors influencing clinical outcomes following methadone overdose in children. We report a 3\u2010year\u2010old child with severe brain injury and death following accidental ingestion of methadone. Our case is unique in that we were able to acquire a serum methadone level following ingestion, which was used to guide intervention and treatments. Using this case, we aim to contribute to the growing understanding of methadone toxicity while also advocating for the implementation of policies that protect our pediatric population.<\/jats:p>","DOI":"10.1155\/crpe\/1045330","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T07:48:36Z","timestamp":1752220116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Accidental Methadone Toxicity in a 3\u2010Year\u2010Old Leading to Severe Cerebellitis and Death: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5241-7923","authenticated-orcid":false,"given":"Jessie","family":"Pappin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/PGMJ.2004.022988"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000950"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200208000-00001"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.AJEM.2005.05.001"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/JECH.51.4.435"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.5812\/IJP.176"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00247-007-0635-6"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/S12880-020-0410-9"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/PAN.12385"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.FORSCIINT.2013.01.028"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/JAT\/BKR013"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0B013E318196FAFF"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ARCHDISCHILD-2012-301728.2"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241140-00003"},{"key":"e_1_2_10_15_2","article-title":"N-acetylcysteine","author":"Ershad M.","year":"2024","journal-title":"History of Modern Clinical Toxicology"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEULET.2020.135177"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/341826"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.DRUGALCDEP.2012.01.013"},{"key":"e_1_2_10_19_2","volume-title":"Prescription Opioid Trends in Canada","author":"St-Martin P.","year":"2023"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/PCH\/19.3.139"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/1045330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crpe\/1045330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/1045330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:05:01Z","timestamp":1773774301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpe\/1045330"}},"subtitle":[],"editor":[{"given":"Vjekoslav","family":"Krzelj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crpe\/1045330"],"URL":"https:\/\/doi.org\/10.1155\/crpe\/1045330","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1045330"}}