{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:54:09Z","timestamp":1788814449331,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":303,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      M\u00e9n\u00e9trier\u2019s disease (MD) is a rare protein\u2010losing gastropathy characterized by hypertrophy of the gastric mucosa, particularly in the fundus and body, leading to hypoalbuminemia and peripheral edema. The etiology remains unclear, but in children, MD is frequently associated with\n                      <jats:italic>Cytomegalovirus<\/jats:italic>\n                      (CMV) infection. Pediatric cases usually have an acute, self\u2010limiting course and may respond to supportive care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We present a case of a 3\u2010year\u2010old previously healthy male who developed vomiting, fatigue, and progressive edema, including facial, limb, and testicular swelling. Laboratory evaluation revealed significant hypoalbuminemia (2.3\u2009g\/dL), hypoproteinemia, hypogammaglobulinemia, elevated triglycerides, and lymphocytosis. Abdominal ultrasound showed free fluid and dilated bowel loops. Esophagogastroduodenoscopy revealed thickened gastric folds, and biopsy confirmed MD with CMV inclusion bodies and positive CMV immunostaining, despite negative CMV PCR and serology. The patient received supportive treatment including albumin infusions, diuretics, high\u2010protein diet, and IV ganciclovir, with clinical improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case reinforces the known association between CMV and MD in children and highlights the variability of CMV detection via PCR or serology. Although pediatric MD is often self\u2010limiting, antiviral therapy may be indicated in severe cases or when supportive care is insufficient. The presence of hypogammaglobulinemia in this case also raises questions about potential underlying immunodeficiency. Clinicians should maintain a high index of suspicion for CMV\u2010associated MD in children with acute\u2010onset edema and hypoalbuminemia, even when routine viral testing is negative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crpe\/2471369","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:35:55Z","timestamp":1761921355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pediatric M\u00e9n\u00e9trier\u2019s Disease Triggered by\n                    <i>Cytomegalovirus<\/i>\n                    Infection: A Rare Case of Severe Hypoalbuminemia and Edema"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3744-6865","authenticated-orcid":false,"given":"Issa","family":"Snoubar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Alhendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Batanji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Nabresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutaz","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Bannoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamaledein","family":"Einar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i23.6943"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.01.2012.5679"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-011-9689-X"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03782-6"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.220061"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000007827"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0009922816657155"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.10.2588-2589.1996"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2019.03.005"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2013.16.2.123"},{"key":"e_1_2_7_11_2","first-page":"291","article-title":"M\u00e9n\u00e9trier\u2019s Disease and Severe Gastric Ulcers Associated With Cytomegalovirus Infection in an Immunocompetent Child: A Case Report","volume":"50","author":"Canan O.","year":"2008","journal-title":"Turkish Journal of Pediatrics"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1993.tb10952.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0791-1"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/2471369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crpe\/2471369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/2471369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:06:04Z","timestamp":1773774364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpe\/2471369"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Scaramuzza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crpe\/2471369"],"URL":"https:\/\/doi.org\/10.1155\/crpe\/2471369","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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