{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:57:15Z","timestamp":1790906235952,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    We describe the case of an eight\u2010year\u2010old female presenting with abrupt\u2010onset involuntary movements, emotional lability, and gait disturbances, consistent with Sydenham\u2019s chorea (SC). Her condition deteriorated despite initial antibiotic treatment and symptomatic management. Notable findings included elevated antistreptolysin O titers and antideoxyribonuclease B antibodies, suggestive of recent Group\n                    <jats:italic>A Streptococcus<\/jats:italic>\n                    infection. Brain magnetic resonance imaging revealed punctate gliosis in the supratentorial white matter, and extensive workup excluded alternative diagnoses. Despite escalating therapy with valproic acid, clonidine, and haloperidol, the patient exhibited persistent choreiform movements and emotional dysregulation. High\u2010dose corticosteroids (methylprednisolone) were initiated, resulting in significant symptomatic improvement and restoration of ambulatory function. Long\u2010term prophylaxis with benzathine penicillin G was implemented to prevent recurrence. SC remains an under\u2010researched complication of acute rheumatic fever, with treatment often extrapolated from limited case reports and expert consensus. This case underscores the potential role of corticosteroids in refractory SC. This case also highlights the complexity of managing prolonged SC and the importance of individualized, multifaceted treatment strategies.\n                  <\/jats:p>","DOI":"10.1155\/crpe\/3533017","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:34:31Z","timestamp":1761219271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Refractory Case of Sydenham Chorea Managed With Intravenous Pulse\u2010Dose Methylprednisolone"],"prefix":"10.1155","volume":"2025","author":[{"given":"Andrea","family":"Weitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-7238","authenticated-orcid":false,"given":"Inna","family":"Kaminecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark","family":"Azubuike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria L.","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Pranathi","family":"Bingi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessyca T.","family":"Cripps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Baiyeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gasque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490150121036"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000205"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.191959"},{"key":"e_1_2_9_4_2","volume-title":"StatPearls [Internet]. Treasure Island (FL)","author":"Beier K.","year":"2024"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01955239"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3035"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.376"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40734-014-0012-1"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.6792"},{"key":"e_1_2_9_10_2","first-page":"300","article-title":"Clinical and Neuroimaging Findings of Sydenham\u2019s Chorea","volume":"24","author":"Ekici A.","year":"2014","journal-title":"Iranian Journal of Pediatrics (English edition)"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3606"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-0999-8"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12786"},{"key":"e_1_2_9_14_2","unstructured":"GilbertD. 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