{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:44:53Z","timestamp":1777869893372,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":119,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Acute osteomyelitis in children is typically a localized hematogenous infection; however, its presentation with deep vein thrombosis (DVT) and septic pulmonary emboli (SPE) is exceptionally rare. Fewer than fifteen similar cases have been reported in the literature. We describe two previously healthy pediatric patients who developed multifocal osteomyelitis, DVT, and SPE in the setting of methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) bacteremia. Both children initially presented with nonspecific limb pain, fever, and markedly elevated inflammatory markers, with early imaging proving nondiagnostic. Each subsequently developed venous thrombosis and septic emboli prior to confirmation of osteomyelitis, reflecting an aggressive clinical pattern. MRI later revealed multifocal bone involvement with subperiosteal abscesses requiring surgical drainage. Management required prolonged targeted intravenous antibiotics, anticoagulation, and coordinated multidisciplinary care. These cases highlight the importance of early suspicion for musculoskeletal infection in febrile children with persistent limb pain and systemic MRSA infection. Early MRI and prompt recognition of thromboembolic complications are essential for improving outcomes.\n                  <\/jats:p>","DOI":"10.1155\/crpe\/3736016","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:56:48Z","timestamp":1777561008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncommon Complications of Osteomyelitis: Deep Vein Thrombosis and Pulmonary Septic Emboli in Two Healthy Pediatric Patients: A Case Report and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5054-5571","authenticated-orcid":false,"given":"Hala O.","family":"Abdallah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8834-7425","authenticated-orcid":false,"given":"Lara Haj","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8061-0971","authenticated-orcid":false,"given":"Hobab Jehad","family":"Odeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-8856","authenticated-orcid":false,"given":"Alma Abu","family":"Lil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amjad","family":"Rajab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"crossref","unstructured":"FelmanA. H.andShulmanS. T. Staphylococcal Osteomyelitis Sepsis and Pulmonary Disease 1975.","DOI":"10.1148\/117.3.649"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.12.012"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12245-008-0006-6"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2011.02.018"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200x.2004.01952.x"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/pec.0b013e3181bda2c6"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/pec.0b013e318267ea4e"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-023-04172-w"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijregi.2023.05.006"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.55248\/gengpi.6.0625.2414"},{"key":"e_1_2_13_11_2","doi-asserted-by":"crossref","first-page":"004","DOI":"10.29328\/journal.aceo.1001022","article-title":"Bacteremia with the Triad Osteomyelitis, Deep Vein Thrombosis, and Pulmonary Septic Emboli in Pediatric Age: a Case Report","volume":"9","author":"Marisol Holanda P.","year":"2025","journal-title":"Archives of Clinical and Experimental Orthopaedics"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.80057"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/3736016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crpe\/3736016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/3736016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:56:50Z","timestamp":1777561010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpe\/3736016"}},"subtitle":[],"editor":[{"given":"Vjekoslav","family":"Krzelj","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crpe\/3736016"],"URL":"https:\/\/doi.org\/10.1155\/crpe\/3736016","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3736016"}}