{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:56:36Z","timestamp":1790574996227,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":269,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anophthalmia is a rare congenital ocular malformation characterized by the complete absence of the eye and its associated ocular structures. Bilateral anophthalmia is particularly uncommon and is frequently associated with multisystem congenital anomalies. Congenital heart disease represents one of the most commonly reported systemic associations; therefore, all infants diagnosed with bilateral anophthalmia should undergo comprehensive systemic evaluation, including detailed cardiovascular assessment. However, the coexistence of bilateral anophthalmia with multiple congenital cardiac defects remains uncommon, with only a limited number of cases reported in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report the case of a 3\u2010day\u2010old full\u2010term Somali male neonate, born in a resource\u2010limited rural setting, who presented with the complete bilateral absence of the ocular globes, which was identified immediately after birth. Ophthalmologic examination confirmed bilateral congenital anophthalmia. During hospitalization, the infant developed clinical features of hemodynamically significant left\u2010to\u2010right shunt physiology, including tachypnea during feeding, feeding difficulties, easy fatigability, and diaphoresis. Brain magnetic resonance imaging confirmed complete bilateral anophthalmia without associated intracranial abnormalities. Transthoracic echocardiography demonstrated multiple congenital cardiac defects, including a 4\u2010mm muscular ventricular septal defect, a 4\u2010mm secundum atrial septal defect associated with an atrial septal aneurysm, and a 3\u2010mm patent ductus arteriosus with restrictive left\u2010to\u2010right shunting. Owing to the hemodynamic significance of these lesions and the lack of advanced pediatric cardiac surgical services locally, the patient was stabilized and referred abroad for definitive surgical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores the rarity of bilateral congenital anophthalmia associated with multiple congenital cardiac anomalies and highlights the critical need for thorough systemic evaluation of neonates with major congenital malformations. Early multidisciplinary involvement and timely referral to specialized centers are essential, particularly in resource\u2010limited settings where diagnostic and therapeutic options are constrained.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crpe\/4616554","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:27:26Z","timestamp":1790573246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral Anophthalmia Associated With Ventricular Septal Defect, Atrial Septal Defect, and Patent Ductus Arteriosus: A Rare Neonatal Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6729-1311","authenticated-orcid":false,"given":"Abdullahi Ali","family":"Roble","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0596-1106","authenticated-orcid":false,"given":"Abdisalam Ismail","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6235-9130","authenticated-orcid":false,"given":"Said Abdi","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-9387","authenticated-orcid":false,"given":"Hassan Muhumed","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-9251","authenticated-orcid":false,"given":"Ishak Ahmed","family":"Abdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8719-8328","authenticated-orcid":false,"given":"Abdijalil Abdullahi","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7803-7364","authenticated-orcid":false,"given":"Balqiz Mohamed","family":"Kulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6848-6015","authenticated-orcid":false,"given":"Ahmed Shafie","family":"Aden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Hassan Hirei","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4199-5502","authenticated-orcid":false,"given":"Mohamed Osman Dahir","family":"Alasow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuayb Abdullahi","family":"Adan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7992-506X","authenticated-orcid":false,"given":"Ahmed Muhamad","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omaf133"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-47"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1951.tb05859.x"},{"key":"e_1_2_13_4_2","volume-title":"Developmenta; Abnormalities of the Third Eye","author":"Mann I.","year":"1957"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2021.09.001"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12543"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-025-03673-0"},{"key":"e_1_2_13_8_2","unstructured":"Lalit GuptaD. A.andManoharM. Anesthetic Considerations in Bilateral Congenital Anophthalmia: A Rare Clinical Entity."},{"key":"e_1_2_13_9_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/archopht.126.5.709","article-title":"Novel SOX2 Mutation Associated With Ocular Coloboma in a Chinese Family","volume":"126","author":"Wang P.","year":"2008","journal-title":"Archives of Ophthalmology"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.9.623"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/iop.0b013e31829f3b29"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62518"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513811003796953"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.2155"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12497"},{"key":"e_1_2_13_16_2","article-title":"Matthew-Wood Syndrome Presenting With Bilateral Anophthalmia and Severe Pulmonary Hypoplasia: A Case Report","volume":"230","author":"Braet C.","year":"2026","journal-title":"Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.63319"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62133"},{"key":"e_1_2_13_19_2","article-title":"Rare Association of Anophthalmia, Complex Congenital Heart Disease and Pulmonary Hypertension: Case Report","volume":"16","author":"R\u00edos-M\u00e9ndez R. 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