{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:01:35Z","timestamp":1784872895547,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":203,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ohtahara syndrome (OS) features neonatal\u2010onset tonic spasms with suppression\u2013burst EEG, high early mortality, and evolution to other epileptic encephalopathies. Respiratory complications are frequent yet underdescribed longitudinally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>We followed a female with neonatal\u2010onset OS and suppression\u2013burst EEG to the age of seven. Despite combination antiseizure therapy (phenobarbital, levetiracetam, vigabatrin, and clonazepam), she had breakthrough events and severe developmental impairment. Between the ages 1 and 7\u2009years, she experienced \u2265 15 documented hospitalizations for recurrent bronchopneumonia, frequently with hypoxemia requiring supplemental oxygen; several episodes were accompanied by seizure exacerbations and clinical aspiration or choking events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and Outcomes<\/jats:title>\n                    <jats:p>Admissions were managed with supportive respiratory care (oxygen, bronchodilators, and corticosteroids when indicated) and broad\u2010spectrum antimicrobials alongside ongoing seizure management, enabling survival to school age in a resource\u2010limited context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In OS, respiratory complications, often driven by aspiration risk and impaired airway clearance, can become a dominant source of morbidity and should be addressed with the same priority as antiseizure therapy. We highlight practical pillars for long\u2010term care: proactive infection prevention and early treatment pathways; aspiration\u2010risk assessment with feeding\/swallow support when feasible; airway\u2010clearance planning with bronchodilator trials during illnesses; judicious corticosteroid use; and caregiver education with explicit thresholds for escalation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crpe\/5989045","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:04:31Z","timestamp":1784869471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seven\u2010Year Longitudinal Respiratory Morbidity in Ohtahara Syndrome: A Case Report Emphasizing Integrated Airway and Seizure Care in a Resource\u2010Limited Setting"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1111-3360","authenticated-orcid":false,"given":"Fadi","family":"Abualhommos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2835-0429","authenticated-orcid":false,"given":"Moath","family":"Hattab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masara","family":"Samara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Suleiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas","family":"Samara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Abukhater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isra","family":"Salman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17239"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64076-5.00030-2"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.09.004"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.06.002"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/501981"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-8508222\/v2"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"},{"key":"e_1_2_13_8_2","first-page":"1","article-title":"Epileptic Encephalopathies of Infancy","volume":"12","author":"Ohtahara S.","year":"2007","journal-title":"Neurology Asia"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3291.ijcp20211692"},{"key":"e_1_2_13_10_2","volume-title":"Lennox-Gastaut Syndrome","author":"Amrutkar C. 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Asia Pacific","volume":"4","author":"Bael M.","year":"2025","journal-title":"Journal of Paediatrics and Child Health"},{"key":"e_1_2_13_21_2","first-page":"69","article-title":"Newborn with Ohtahara syndrome and Absence of Respiratory Trigger: Ethical Issues in the NICU","volume":"72","author":"Corsano B.","year":"2023","journal-title":"Medicina e Morale"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812464395"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/26323524251326103"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-824535-4.00008-2"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/5989045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crpe\/5989045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/5989045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:04:33Z","timestamp":1784869473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpe\/5989045"}},"subtitle":[],"editor":[{"given":"Baisakhi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crpe\/5989045"],"URL":"https:\/\/doi.org\/10.1155\/crpe\/5989045","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5989045"}}