{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:44:13Z","timestamp":1785825853016,"version":"3.56.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":214,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Neonatal hematemesis is an uncommon presentation with a broad differential diagnosis ranging from benign to life\u2010threatening etiologies, and there are no well\u2010established, evidence\u2010based management guidelines. This case highlights the diagnostic challenges and potential role of empiric acid suppression in a clinically stable neonate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case(s) Presentation<\/jats:title>\n                    <jats:p>A 4\u2010week\u2010old term male with a prior episode of coffee\u2010ground emesis at 3\u2009days of life presented with recurrent hematemesis consisting of bright red blood. He was hemodynamically stable with an unremarkable physical exam. Laboratory evaluation demonstrated stable hemoglobin, mildly elevated bilirubin, and no evidence of coagulopathy. Imaging, including abdominal ultrasound and radiographs, was unremarkable. Infectious and hematologic workups were negative. Esophagogastroduodenoscopy revealed superficial gastric mucosal abrasions without active bleeding, ulcers, or structural abnormalities. The patient was managed initially with intravenous acid suppression and supportive care, and then transitioned to oral lansoprazole. He tolerated feeds without recurrence of hematemesis and was discharged with a 14\u2010day course of proton pump inhibitor therapy. At two\u2010week follow\u2010up, he remained asymptomatic with normal feeding and no further bleeding episodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores the importance of systematic evaluation in neonatal hematemesis and suggests that empiric proton pump inhibitor therapy may be a reasonable option in select stable patients with suspected mucosal injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crpe\/6283741","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:54:59Z","timestamp":1785822899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Report of Hematemesis in a 4\u2010Week\u2010Old Neonate: Clinical Reasoning and Outcome After Empiric Acid Suppression"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7318-3709","authenticated-orcid":false,"given":"Nora","family":"Lyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4150-1918","authenticated-orcid":false,"given":"Daisy","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2807-1090","authenticated-orcid":false,"given":"Amy","family":"Phu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadira","family":"Arguelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6161-3568","authenticated-orcid":false,"given":"Thiagarajan","family":"Nandhagopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/1084713806297151"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051346"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(01)04005-9"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011785.pub2"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-023-00580-z"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005415.pub4"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000001889"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/neo.24-6-e403"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2015.09.003"},{"key":"e_1_2_11_10_2","unstructured":"BalkianA.andLamphierK. A. GershelJ. C.andRauchD. A. Medicine AAoPSoH. Gastrointestinal Bleeding Caring for the Hospitalized Child: A Handbook of Inpatient Pediatrics American Academy of Pediatrics."},{"key":"e_1_2_11_11_2","first-page":"169","article-title":"The Role of Proton Pump Inhibitors in the Management of Upper Gastrointestinal Disorders","volume":"14","author":"Ali Khan M.","year":"2018","journal-title":"Gastroenterology and Hepatology"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i47.6095"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001245"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/6283741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crpe\/6283741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/6283741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:55:00Z","timestamp":1785822900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpe\/6283741"}},"subtitle":[],"editor":[{"given":"Baisakhi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crpe\/6283741"],"URL":"https:\/\/doi.org\/10.1155\/crpe\/6283741","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6283741"}}