{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:27:02Z","timestamp":1786951622420,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":228,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Accurate diagnosis of bacterial meningitis is critical, particularly in young febrile infants. Although commercially available multiplex PCR assays enable rapid pathogen detection, these typically do not include\n                    <jats:italic>Salmonella<\/jats:italic>\n                    spp. or other Enterobacteriaceae, which may result in missed diagnoses and\/or inappropriate treatment duration. We report the case of a 2\u2010month\u2010old female infant with\n                    <jats:italic>Salmonella enteritidis<\/jats:italic>\n                    meningitis and concurrent bacteremia. The patient initially presented with fever, lethargy, and a bulging anterior fontanelle. Cerebrospinal fluid (CSF) analysis was highly suggestive of bacterial meningitis. However, both CSF culture and the FilmArray ME Panel were negative, likely due to prior empirical antibiotic therapy at another hospital. The causative organism was isolated on blood cultures. The infant was treated with intravenous ceftriaxone for 24\u2009days and discharged in excellent clinical condition. Twelve days later, she was readmitted with a relapse of meningitis and bacteremia caused by the same pathogen. She received combination therapy with cefotaxime and cotrimoxazole for 37\u2009days, followed by cefotaxime monotherapy for another 26\u2009days. Immunological evaluation, including assessment of immunoglobulin levels, lymphocyte subsets, and interferon\u2010\u03b3 receptor and Interleukin\u201012 receptor expression, was normal. The patient had a favorable outcome with complete clinical and laboratory recovery and a normal neurodevelopmental outcome at follow\u2010up.\n                    <jats:italic>Salmonella<\/jats:italic>\n                    meningitis is a rare but life\u2010threatening condition in infants, which may be overlooked when relying on molecular diagnostic panels that do not include this pathogen. Negative CSF PCR results should be interpreted with caution in the presence of typical cytological and biochemical findings of bacterial meningitis. Prolonged antimicrobial therapy of at least 4\u20136\u2009weeks is essential to prevent relapse and ensure optimal microbiologic and clinical outcomes.\n                  <\/jats:p>","DOI":"10.1155\/crpe\/6662180","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:20:42Z","timestamp":1786951242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relapsing Salmonella Meningitis in an Infant: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-4277","authenticated-orcid":false,"given":"Sonia","family":"Alexiadou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-9733","authenticated-orcid":false,"given":"Elpis","family":"Mantadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8038-4229","authenticated-orcid":false,"given":"Ioanna","family":"Irakleidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4079-5715","authenticated-orcid":false,"given":"Stavroula","family":"Kalatzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3352-773X","authenticated-orcid":false,"given":"Eleni","family":"Myrtzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2649-4657","authenticated-orcid":false,"given":"Evlampia A.","family":"Psatha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-0285","authenticated-orcid":false,"given":"Dimitrios","family":"Cassimos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000335"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/s1481803500015876"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.5.1169"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2005005"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf155"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.14740\/ijcp236w"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1103.040694"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-205082"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-056140"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ789"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1696977"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-30"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ685"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069783"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1201-9712(03)90043-9"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1179\/146532809X401980"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.103776"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.2174\/0118715265286206240402050756"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.4172\/2324-853X.1000109"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5368.1435"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2019.10.008"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08645-7"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.5.653"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2022.0227"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2655801"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.69146"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-6-881"},{"key":"e_1_2_13_28_2","doi-asserted-by":"crossref","unstructured":"KimberlinD. 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Red Book: 2021\u20132024 Report of the Committee on Infectious Diseases 32nd edition American Academy of Pediatrics Itasca IL.","DOI":"10.1542\/9781610027373"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v90i2.6866"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004417"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/6662180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crpe\/6662180","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/6662180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:20:44Z","timestamp":1786951244000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpe\/6662180"}},"subtitle":[],"editor":[{"given":"Baisakhi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crpe\/6662180"],"URL":"https:\/\/doi.org\/10.1155\/crpe\/6662180","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6662180"}}