{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:48:44Z","timestamp":1777283324071,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":116,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Congenital candidiasis is a rare but potentially lethal disease in preterm infants. Most cases are caused by\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    ; to date, there are no reports of\n                    <jats:italic>Candida dubliniensis<\/jats:italic>\n                    as the causative organism. Herein, we report a case of severe congenital candidiasis caused by\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>dubliniensis<\/jats:italic>\n                    in a very low\u2010birth\u2010weight infant. The patient was treated with fosfluconazole intravenously. However, candidiasis infection relapsed on Day 8 of life. Therefore, fosfluconazole administration was switched to 10\u2009mg\/kg\/day of micafungin for the next 14\u2009days as the inhibitory concentration of micafungin was lower than that of fluconazole. The candidiasis did not relapse again after discontinuation of micafungin. The patient was discharged on Day 59 without apparent sequelae. Some experiments have induced stable fluconazole resistance in vitro in fluconazole\u2010sensitive\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>dubliniensis<\/jats:italic>\n                    strains after exposure to low concentrations of fluconazole. It may be advisable to consider an alternative antifungal drug when\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>dubliniensis<\/jats:italic>\n                    is a causative organism.\n                  <\/jats:p>","DOI":"10.1155\/crpe\/7680042","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:08:03Z","timestamp":1777280883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe Congenital Candidiasis due to\n                    <i>Candida dubliniensis<\/i>\n                    Treated With Fosfluconazole in a Preterm Infant"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-9024","authenticated-orcid":false,"given":"Hiroyuki","family":"Higashiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-3470","authenticated-orcid":false,"given":"Takeshi","family":"Futatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.2.438"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.47162\/rjme.61.3.05"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1614725"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01759.x"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/jlp.jlp_1_18"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0255-0857(21)01822-3"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-26.2.115"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz287"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.10.006"},{"key":"e_1_2_11_10_2","article-title":"Antifungal Susceptibility Pattern of Candida Species Isolated from Pregnant Women","volume":"14","author":"Ali M.","year":"2024","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.41.3.617"},{"key":"e_1_2_11_12_2","article-title":"Fluconazole Population Pharmacokineetics After Fosfluconazole Administration and Dosing Optimization in Extremely-low-birth-weight Infants","volume":"10","author":"Tanzawa A.","year":"2022","journal-title":"Microorganisms"},{"key":"e_1_2_11_13_2","article-title":"Matrix-Assisted Laser Desorption\/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) Analysis for the Identification of Pathogenic Microorganisms: a Review","volume":"9","author":"Chen X. F.","year":"2021","journal-title":"Microorganisms"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0b013e31819f1f50"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1567-1356(03)00240-x"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02494-20"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0000000000001996"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-025-01852-9"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/7680042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crpe\/7680042","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpe\/7680042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:08:04Z","timestamp":1777280884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpe\/7680042"}},"subtitle":[],"editor":[{"given":"Satabdi","family":"Datta Choudhury","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crpe\/7680042"],"URL":"https:\/\/doi.org\/10.1155\/crpe\/7680042","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7680042"}}