{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:45:20Z","timestamp":1773787520263,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":332,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Childhood ischemic stroke is rare. Although the standard treatment for ischemic stroke among adults is thrombolytic therapy with recombinant tissue\u2010type plasminogen activator (rt\u2010PA), its use in pediatric patients remains uncertain. Particularly, only a very few reports have studied this treatment among very young children aged &lt; 3\u2009years. We report the case of a 2.5\u2010year\u2010old boy with complex congenital heart disease who developed left hemiparesis and impaired consciousness. Magnetic resonance (MR) imaging confirmed an acute infarct in the right parieto\u2010occipital lobe. He presented with severe neurological deficits and was treated with rt\u2010PA at 3.5\u2009h after symptom onset. The rt\u2010PA at an adult dosage of 0.6\u2009mg\/kg was administered as an intravenous bolus and infusion. Initial computed tomography showed no hemorrhage. Post\u2010treatment imaging showed recanalization and no new hemorrhage. The patient exhibited remarkable neurological improvement and was neurologically intact at 12\u2009h postadministration. Follow\u2010up MR imaging performed on Day 16 showed no evidence of ischemia. MR angiography clearly demonstrated the right parieto\u2010occipital artery, which was not depicted on the initial MR images. Our case represents a rare instance of the use of rt\u2010PA in a young child. Despite limited data and absence of pediatric\u2010specific guidelines, this report suggests that rt\u2010PA is effective and can be administered safely in young children with acute ischemic stroke, mirroring adult treatment protocols. However, further research is necessary to establish definitive pediatric guidelines.<\/jats:p>","DOI":"10.1155\/crpe\/8259781","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T08:35:08Z","timestamp":1764405308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiogenic Embolism Treated Successfully by Intravenous Recombinant Tissue\u2010Type Plasminogen Activator Administration in a Young Child With Congenital Heart Disease: A Case 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