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Prazosin, an alpha\u20101 adrenergic antagonist, has been commonly used off\u2010label for the treatment of these intrusion symptoms, although its short half\u2010life makes it so that often multiple doses are needed. Doxazosin, another alpha\u20101 antagonist, is starting to be investigated in the treatment of PTSD\u2010related nightmares due to its lesser side effect profile and longer half\u2010life. In our case series, we present three cases of patients with PTSD\u2010related nightmares who were successfully treated with doxazosin following a relapse of symptoms after discontinuation of prazosin for various reasons. The success of doxazosin immediate release for PTSD\u2010related nightmares warrants further studies into its efficacy and use as an alternative treatment to prazosin.<\/jats:p>","DOI":"10.1155\/crps\/6452923","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T13:32:58Z","timestamp":1732627978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Doxazosin Immediate Release as a Novel Treatment for Nightmares in Posttraumatic Stress Disorder"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9714-4151","authenticated-orcid":false,"given":"Danyaal","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-2904","authenticated-orcid":false,"given":"Christie","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0880-8210","authenticated-orcid":false,"given":"Martin","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.08.001"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.2.022305.095305"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22360"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejtd.2023.100335"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12820"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/24740527.2018.1435994"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2007.03.002"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02249755"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010818-021701"},{"key":"e_1_2_9_10_2","first-page":"546","article-title":"A Review of PTSD and Current Treatment Strategies","volume":"118","author":"Schrader C.","year":"2021","journal-title":"Missouri Medicine: Journal of the Missouri State Medical Association"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pra.0000452561.98286.1e"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197902013000505"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00929-x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.9740\/mhc.2022.08.267"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09681"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.3928\/00485713-20160728-01"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2020.0411"},{"key":"e_1_2_9_18_2","volume-title":"StatPearls","author":"Kim J.","year":"2024"},{"key":"e_1_2_9_19_2","unstructured":"Pfizer Inc. CARDURA XL-Doxazosin Mesylate Tablet Multilayer Extended Release 2024 https:\/\/www.pfizer.com\/products\/product-detail\/cardura_xl."},{"key":"e_1_2_9_20_2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1176\/appi.focus.16408","article-title":"VA\/DOD Clinical Practice Guideline for the Management of Post-Traumatic Stress Disorder and Acute Stress Disorder: Clinician Summary","volume":"16","author":"VA\/DoD Clinical Practice Guidelines","year":"2018","journal-title":"Focus"},{"key":"e_1_2_9_21_2","unstructured":"AlexanderW. 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