{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:36:55Z","timestamp":1773787015217,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":240,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Delayed posthypoxic leukoencephalopathy (DPHL) is a rare diagnosis that may present similarly to other more common neurological conditions, such as catatonia. While often seen with carbon\u2013monoxide poisoning, it can also be due to anoxia due to other causes, such as drug overdose or cardiac arrest. Due to the delayed nature of its symptoms and overlap with other conditions, it can be initially misdiagnosed. We present a 50\u2010year\u2010old female patient with a history of depression who was found unresponsive, hypoxic, and febrile at her home for an unknown amount of time. The initial concern was for sepsis. Initial computed tomography (CT) of the head and magnetic resonance imaging (MRI) of the brain were normal. The patient had rhabdomyolysis with secondary renal failure, shock liver, and acute pancreatitis. Once medically stabilized, her cognition returned to a normal baseline. However, 10 days into her hospitalization, her mental state deteriorated, displaying symptoms of mutism, stupor, staring, decreased oral intake, and perseveration. Catatonia, secondary to a major depressive episode, was suspected. Lorazepam was titrated upward without result. Lack of response to lorazepam prompted a repeat brain MRI, revealing diffuse white matter changes in the frontal, temporal, parietal, and occipital lobes of both hemispheres. A diagnosis of DPHL was made. She was then started on carbidopa\/levodopa 25\/100\u2009mg with improvement and was discharged to a rehabilitation facility.<\/jats:p>","DOI":"10.1155\/crps\/9978149","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:37:21Z","timestamp":1756460241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed Posthypoxic Leukoencephalopathy in a Catatonic\u2010Appearing Patient: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7989-9010","authenticated-orcid":false,"given":"Meredith","family":"Bentley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Gaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Hostetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Holroyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Pickstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Melvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2008.20.4.473"},{"key":"e_1_2_10_2_2","first-page":"1424","article-title":"Metachromatic Leukodystrophy: Diffusion MR Imaging Findings","volume":"23","author":"Sener R. N.","year":"2002","journal-title":"American journal of neuroradiology"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.42.6.530"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v6.i4.391"},{"key":"e_1_2_10_5_2","article-title":"Catatonia: Treatment and Prognosis","author":"Coffey J. M.","year":"2017","journal-title":"UpToDate"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2010-0536"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144913"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.364"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.4081\/ni.2013.e13"},{"key":"e_1_2_10_10_2","unstructured":"BentleyM. GaalJ. HostetterJ. andMelvinK. A Case of Delayed Post-Hypoxic Leukoencephalopathy in a Catatonic-Appearing Patient American Psychiatric Association Annual Meeting New York NY 2018."},{"key":"e_1_2_10_11_2","unstructured":"GaalJ. 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L. \u201cNo. 87 A Case of Delayed Post-Hypoxic Leukoencephalopathy in a Catatonic-Appearing Patient https:\/\/cris.vub.be\/ws\/portalfiles\/portal\/37906001\/Poster_Proceedings.pdf."}],"container-title":["Case Reports in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crps\/9978149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crps\/9978149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crps\/9978149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:58:23Z","timestamp":1773773903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crps\/9978149"}},"subtitle":[],"editor":[{"given":"Nikhat","family":"Kaura","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crps\/9978149"],"URL":"https:\/\/doi.org\/10.1155\/crps\/9978149","archive":["Portico"],"relation":{},"ISSN":["2090-682X","2090-6838"],"issn-type":[{"value":"2090-682X","type":"print"},{"value":"2090-6838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9978149"}}