{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:45:48Z","timestamp":1772981148191,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clozapine has shown to be effective as an off\u2010label treatment for aggressive behavior in patients with borderline personality disorder (BPD) and mild intellectual disability (MID). However, there is a lack of empirical evidence for its efficacy in these patient populations and results are so far heterogeneous.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 40\u2010year\u2010old woman diagnosed with BPD and MID with severe and treatment\u2010resistant aggressive behavior was treated off\u2010label with clozapine. A carefully administered treatment with slow titration led to a significant reduction in self\u2010aggressive behavior and termination of aggressive behavior towards others over a 26\u2010week observation period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our case highlights the potential efficacy of clozapine as an off\u2010label treatment for severe and treatment\u2010resistant aggressive behavior in patients with combined BPD and MID. Clozapine should be considered as a therapeutic option in severe and complex cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crps\/9991035","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T15:39:49Z","timestamp":1769873989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clozapine as an Off\u2010Label Treatment for Severe and Treatment\u2010Resistant (Auto\u2010)Aggressive Behavior in a 40\u2010Year\u2010Old Patient With Mild Intellecutal Disability and Borderline Personality Disorder"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1278-9427","authenticated-orcid":false,"given":"Lukas","family":"Zabel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Ersek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-8410","authenticated-orcid":false,"given":"Andreas 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