{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:20:29Z","timestamp":1788340829051,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":244,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pulmonology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal neoplasms with intermediate malignant potential. While most commonly arising in the lung, airway involvement is exceedingly uncommon. Endobronchial IMTs typically manifest with symptoms of airway obstruction, including dyspnea, wheezing, and stridor. Diagnosis involves radiological imaging, bronchoscopic evaluation, and histopathological analysis. Additionally, assessment of anaplastic lymphoma kinase (ALK) status is particularly important in young and pediatric patients, as ALK\u2010targeted therapies constitute a viable treatment option for tumors harboring ALK rearrangements or other actionable kinase fusions. Complete surgical resection remains the gold standard for treatment; however, bronchoscopic resection may be an effective option in selected cases. Herein, we describe two cases of IMTs involving the airways\u2014one in an adult and one in a child\u2014both presenting with significant airway obstruction and managed with bronchoscopic resection.<\/jats:p>","DOI":"10.1155\/crpu\/3123893","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:48:30Z","timestamp":1788338910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory Myofibroblastic Tumor of the Central Airways: Case Report and Review of Diagnostic and Therapeutic Strategies"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4217-6712","authenticated-orcid":false,"given":"Ahmed","family":"Ehab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoufal","family":"Benabdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Yasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2300-239X","authenticated-orcid":false,"given":"Erik","family":"B\u00fcscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6121-4737","authenticated-orcid":false,"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-1325","authenticated-orcid":false,"given":"Kaid","family":"Darwiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213393.57322.c7"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.81"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/amhs.amhs_43_24"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12910"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmr.2022.09.005"},{"key":"e_1_2_10_6_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.rmcr.2014.10.001","article-title":"A Rare Tumor of Trachea: Inflammatory Myofibroblastic Tumor Diagnosis and Endoscopic Treatment","volume":"13","author":"\u00d6zg\u00fcl M. A.","year":"2014","journal-title":"Respiratory Medicine Case Reports"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182952caa"},{"key":"e_1_2_10_8_2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/01455613211014076","article-title":"Inflammatory Myofibroblastic Tumor (IMT) of the Trachea Excised by Transtracheal Surgery: Case Report","volume":"102","author":"Ohba S.","year":"2023","journal-title":"Ear Nose & Throat Journal"},{"key":"e_1_2_10_9_2","doi-asserted-by":"crossref","DOI":"10.1111\/1759-7714.70027","article-title":"Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor","volume":"16","author":"Li S.","year":"2025","journal-title":"Thoracic Cancer"},{"key":"e_1_2_10_10_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/LBR.0b013e31827cd58f","article-title":"Inflammatory Myofibroblastic Tumor of Trachea","volume":"20","author":"Jain S.","year":"2013","journal-title":"Journal of Bronchology & Interventional Pulmonology"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-025-03476-5"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00151-2020"},{"key":"e_1_2_10_13_2","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1200\/JCO.2017.73.4830","article-title":"Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children\u2032s Oncology Group Study","volume":"35","author":"Moss\u00e9 Y. P.","year":"2017","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25043"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.016"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182915cef"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1260"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/PO.18.00297"}],"container-title":["Case Reports in Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpu\/3123893","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crpu\/3123893","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpu\/3123893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:48:32Z","timestamp":1788338912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpu\/3123893"}},"subtitle":[],"editor":[{"given":"Nidhi","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crpu\/3123893"],"URL":"https:\/\/doi.org\/10.1155\/crpu\/3123893","archive":["Portico"],"relation":{},"ISSN":["2090-6846","2090-6854"],"issn-type":[{"value":"2090-6846","type":"print"},{"value":"2090-6854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3123893"}}