{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:56:33Z","timestamp":1773014193062,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pulmonology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Multidrug\u2010resistant (MDR) anal and perianal tuberculosis constitutes an exceptionally rare form of extrapulmonary tuberculosis. We report a case of MDR anal and perianal tuberculosis diagnosed and managed in the Pneumo\u2010Phthisiology Department of Ignace Deen University Hospital in Conakry, Guinea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>\n                      Mrs. M.B., a 33\u2010year\u2010old housewife residing in Tombolia (Conakry), with no notable medical history, presented to the General Surgery Department of Ignace Deen University Hospital on 24 February 2023 with fever, abdominal pain, constipation, and painful swelling of the anal and perianal region. Following a hemorrhoidectomy, histopathological examination of the surgical specimen initially suggested a diagnosis of diffuse large B\u2010cell lymphoma of the anal region. Consequently, CHOP chemotherapy (Adriamycin, cyclophosphamide, vincristine, and prednisolone) was initiated on 10 March 2023 in the Hematology Department. After three cycles of chemotherapy, the patient showed no clinical improvement, with persistent anal lesions and recurrent fever. A strongly positive tuberculin skin test (15\u2009mm) prompted referral to the Pneumo\u2010Phthisiology Department for suspected anal tuberculosis. GeneXpert MTB\/RIF testing performed on stool samples confirmed the presence of MDR\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      . A 9\u2010month short\u2010course second\u2010line antituberculosis regimen was initiated. After 1 month of treatment, the patient developed abdominal pain, semiliquid diarrhea, anorexia, and abdominal distension with a positive fluid\u2010thrill sign. The anal and perianal lesions, however, showed significant improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MDR anal and perianal tuberculosis is an uncommon manifestation of extrapulmonary tuberculosis. In regions with high tuberculosis endemicity, it should be considered in the differential diagnosis of chronic ulcerative cutaneous or mucosal lesions. Management relies primarily on second\u2010line antituberculosis therapy to prevent complications and ensure complete recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crpu\/3497569","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:43:24Z","timestamp":1773009804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidrug\u2010Resistant Anal and Perianal Tuberculosis: A Case Report From the Pneumo\u2010Phthisiology Department of Conakry University Hospital, Guinea"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5004-3652","authenticated-orcid":false,"given":"Oumou Hawa","family":"Diallo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamadou Hawa","family":"Camara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boubacar Djelo","family":"Diallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierno Mouctar","family":"Bah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ousmane N\u2032Namarie","family":"Camara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aboubacar","family":"Camara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lansana Mady","family":"Camara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1333468"},{"key":"e_1_2_9_2_2","unstructured":"World Health Organization WHO. Global Tuberculosis Report 2024 2024 https:\/\/www.who.int\/publications\/i\/item\/9789240101531."},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/685406"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/puh2.160"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed5030109"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/852763"},{"key":"e_1_2_9_7_2","first-page":"65","article-title":"Tuberculose: ganglionnaire et anale \u00e0 Mycobact\u00e9rium tuberculosis d\u2032embl\u00e9e r\u00e9sistante \u00e0 la rifampicine \u00e0 propos d\u2032un cas","volume":"3","author":"Azon-Kouanou A.","year":"2016","journal-title":"Revue Africaine de M\u00e9decine Interne"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12157-012-0357-4"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-8320(07)89334-1"},{"key":"e_1_2_9_10_2","unstructured":"Ministry of Health and Public Hygiene National Directorate of Epidemiology and Disease Control National Tuberculosis Control Program (PNLT) 2023 Annual Report on Tuberculosis Control Activities in Guinea 2024 http:\/\/www.rafmi.org\/index.php\/rafmi\/issue\/view\/11."},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4177"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmy.ijmy_172_24"},{"key":"e_1_2_9_13_2","first-page":"305","article-title":"Abdominal Tuberculosis","volume":"120","author":"Sharma M. 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