{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:35:22Z","timestamp":1773786922328,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Diffuse alveolar hemorrhage (DAH) is a potentially life\u2010threatening condition which can present with hemoptysis, diffuse alveolar infiltrates, anemia, and hypoxic respiratory failure. Antisynthetase syndrome (AS) is a rare autoimmune disorder most often characterized by nonerosive arthritis, proximal muscle weakness with elevated muscle enzymes, Raynaud\u2019s phenomenon, hyperkeratosis of the digits (mechanic\u2019s hands), and interstitial lung disease. According to large population studies, AS has an annual incidence of 0.56 per 100,000 persons and prevalence of 9 per 100,000. The most common autoantibody is anti\u2010aminoacyl\u2010transfer RNA synthetase for histidine (anti\u2010Jo\u20101) with a reported prevalence of 20%\u201330%, whereas anti\u2010Pl\u20107 (for threonine) accounts for less than 5% of all autoimmune myositis. Specific myositis autoantibodies determine clinical phenotype. PL\u20107 is characterized by interstitial lung disease, myositis, and arthritis. Autoimmune myositis, specifically AS, is a rare cause of DAH. Herein, we describe the first reported case of PL\u20107\u2010associated AS with DAH.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    A 41\u2010year\u2010old female presented with worsening shortness of breath and hemoptysis. Laboratory studies included a hemoglobin of 10.5\u2009g\/dL, mildly elevated liver enzymes, and a creatine phosphokinase (CPK) of nearly 4000\u2009U\/L. CT of the chest showed diffuse ground glass opacities bilaterally. Serial aliquots of the bronchoalveolar lavage (BAL) fluid revealed progressively hemorrhagic return and histopathologic analysis consistent with DAH. Other concurrent causes of DAH were ruled out.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Although rare, AS should be considered a cause of DAH, particularly in patients presenting with symptoms of muscle weakness and arthritis or with evidence of mechanic\u2019s hands.\n                  <\/jats:p>","DOI":"10.1155\/crpu\/3715449","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:53:40Z","timestamp":1737096820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diffuse Alveolar Hemorrhage Associated With Anti\u2010PL\u20107 Antisynthetase Syndrome: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7773-1985","authenticated-orcid":false,"given":"Paul","family":"Shiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7975-2123","authenticated-orcid":false,"given":"Shannon","family":"Iriza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1722-4454","authenticated-orcid":false,"given":"Steven","family":"Templeton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2013.74.4.151"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae163.305"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2012-131416"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.07.004"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2017.1420817"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-019-0852-7"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21895"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-37132011000100015"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211174"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164449"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600623791"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.6.7767555"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.1387287"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5453717"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2020.101261"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00359-9"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25348"}],"container-title":["Case Reports in Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpu\/3715449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crpu\/3715449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpu\/3715449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:57:55Z","timestamp":1773773875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpu\/3715449"}},"subtitle":[],"editor":[{"given":"Tun-Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crpu\/3715449"],"URL":"https:\/\/doi.org\/10.1155\/crpu\/3715449","archive":["Portico"],"relation":{},"ISSN":["2090-6846","2090-6854"],"issn-type":[{"value":"2090-6846","type":"print"},{"value":"2090-6854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3715449"}}