{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:46:11Z","timestamp":1767797171106,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pulmonology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cerebrospinal fluid (CSF) rhinorrhea involves drainage of CSF through the nasal cavity due to disruption of the skull base, and pneumonitis secondary to CSF aspiration is a lesser\u2010known complication reported. We present the case of a patient whose pulmonary symptoms and function improved after surgical CSF leak repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a case report with review of the electronic medical record and literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 35\u2010year\u2010old female presented with 1 year of refractory right\u2010sided rhinorrhea and recurrent lower respiratory infections. Nasal drainage was positive for beta\u20102\u2010transferrin. Sinus CT showed a possible leakage site at the right lateral lamella of the cribriform plate. Chest CT showed upper lobe predominant ground\u2010glass opacities. Following surgical CSF leak repair, chest CT showed resolution of ground\u2010glass opacities and pulmonary function testing showed an increase in spirometric lung volumes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aspiration pneumonitis from CSF leaks is rarely reported. Studies report resolution of ground\u2010glass opacities on chest CT as well as clinical improvement in symptoms such as cough following surgical leak repair. Proposed mechanisms leading to aspiration pneumonitis include nasopharyngeal bacterial transit; the mechanism of persistent leak may be related to cough\u2010induced increase in intracranial pressure leading to increased CSF flow. In patients with lower airway inflammation and obstruction as well as unexplained aspiration pneumonitis, a high index of suspicion for CSF rhinorrhea is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crpu\/9651572","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:53:32Z","timestamp":1767786812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resolution of Pulmonary Inflammation and Obstruction Following Repair of Cerebrospinal Fluid Leak: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0355-3666","authenticated-orcid":false,"given":"Ann O.","family":"Birmingham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1848-1254","authenticated-orcid":false,"given":"Serban A.","family":"Staicu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8199-7428","authenticated-orcid":false,"given":"Isaac L.","family":"Schmale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-2096","authenticated-orcid":false,"given":"Li-Xing","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.2169\/INTERNALMEDICINE.8596-21"},{"key":"e_1_2_9_2_2","first-page":"98","volume-title":"Practical Rhinology","author":"Severson M.","year":"2025"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28757"},{"key":"e_1_2_9_4_2","first-page":"E397","article-title":"Cerebrospinal Fluid Rhinorrhoea: Diagnosis and Management","volume":"12","author":"Abuabara A.","year":"2007","journal-title":"Medicina Oral, Patolog\u00eda Oral y Cirug\u00eda Bucal"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000124"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000524"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23306"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22043"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01620-5"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1582238"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202564"}],"container-title":["Case Reports in Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crpu\/9651572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:53:33Z","timestamp":1767786813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crpu\/9651572"}},"subtitle":[],"editor":[{"given":"Tun-Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crpu\/9651572"],"URL":"https:\/\/doi.org\/10.1155\/crpu\/9651572","archive":["Portico"],"relation":{},"ISSN":["2090-6846","2090-6854"],"issn-type":[{"value":"2090-6846","type":"print"},{"value":"2090-6854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9651572"}}