{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:34:44Z","timestamp":1773786884642,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pulmonology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Multidrug\u2010resistant tuberculosis (MDR\u2010TB) is characterized by resistance to at least isoniazid and rifampicin. Linezolid is an antibiotic used for drug\u2010resistant Gram\u2010positive bacteria and is a treatment option for MDR\u2010TB. However, its use is associated with optic neuropathy, presenting as acute worsening and bilateral vision loss, typically within 4 months of therapy. A 47\u2010year\u2010old male with MDR\u2010TB relapsed during the sixth month of an individualized treatment regimen at Dr. Soetomo General Academic Hospital, Surabaya. The patient presented with weakness and anemia, receiving a regimen including levofloxacin (750\u2009mg), linezolid (600\u2009mg), clofazimine (100\u2009mg), and cycloserine (500\u2009mg). In the ninth month, the patient developed visual disturbances, initially suspected to be caused by an intracranial tumor. Despite various examinations and treatments, there was no improvement until linezolid was discontinued. The patient\u2019s visual complaints gradually improved following the cessation of linezolid therapy. This case underscores the potential for linezolid to cause optic neuropathy during prolonged treatment for MDR\u2010TB. Detailed ophthalmologic examinations, including optical coherence tomography (OCT) and magnetic resonance imaging (MRI), confirmed optic neuropathy without intracranial pathology. Despite high\u2010dose steroid therapy, the patient\u2019s vision improved only after 1 month since discontinuing linezolid. This highlights the importance of monitoring for ocular toxicity in patients undergoing long\u2010term linezolid therapy and suggests that timely intervention can prevent permanent visual impairment. The case demonstrates the reversible nature of linezolid\u2010induced optic neuropathy upon drug cessation and emphasizes the need for regular ophthalmologic assessments in patients receiving prolonged linezolid treatment. This report contributes to the understanding of the adverse effects of linezolid and underscores the importance of vigilant monitoring and alternative therapeutic strategies for MDR\u2010TB.<\/jats:p>","DOI":"10.1155\/crpu\/9939815","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T03:19:16Z","timestamp":1753672756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Visual Recovery Following Linezolid Cessation in an MDR\u2010TB Patient: Detailed Case Analysis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6199-3040","authenticated-orcid":false,"given":"Yovil Bagas","family":"Wiyana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-0511","authenticated-orcid":false,"given":"Isnin Anang","family":"Marhana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gatot","family":"Suhartono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2588-0879","authenticated-orcid":false,"given":"Andreas","family":"Haryono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,27]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02452"},{"key":"e_1_2_11_2_2","unstructured":"World Health Organization Global Tuberculosis Report 2021 2021 https:\/\/www.who.int\/publications\/i\/item\/9789240037021."},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012836.pub2"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0222-8"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1201964"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2016.02.010"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0331-4"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0000818"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31882-3"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2013.11.11"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.02.010"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.102541"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.7399\/fh.11133"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162138"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200503000-00005"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2003.10.003"},{"key":"e_1_2_11_17_2","first-page":"223","article-title":"Leber\u2019s Hereditary Optic Neuropathy Differentially Affects Smaller Axons in the Optic Nerve","volume":"98","author":"Sadun B. 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