{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:38:07Z","timestamp":1792269487453,"version":"4.4.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":249,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>We report the case of a 30\u2010year\u2010old Somali female with mixed connective tissue disease (MCTD) who developed dermatomyositis and both scleroderma renal crisis (SRC) and fatal cardiac complications. Notably, she tested positive for both anti\u2010U3 RNP and anti\u2010RNA polymerase III antibodies which is a rare serologic combination. After initial treatment with corticosteroids for dermatomyositis features, she experienced rapid clinical deterioration marked by malignant hypertension and thrombotic microangiopathy and was found to have SRC and diffuse myocardial fibrosis. Despite treatment with captopril and hemodialysis, she ultimately died of cardiac arrest. This case highlights the complexity and risks in managing patients with overlapping autoantibodies and underscores the need for close monitoring and cautious use of steroids in such high\u2010risk individuals.<\/jats:p>","DOI":"10.1155\/crrh\/5033806","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:41:30Z","timestamp":1788795690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Navigating the Unknown: Scleroderma Renal Crisis and a Fatal Cardiac Complication in a Young Patient With MCTD With Coexisting Anti\u2010U3 RNP and Anti\u2010RNA Polymerase III Antibodies"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-3375","authenticated-orcid":false,"given":"Tiago","family":"Reyes-Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Nabizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawad","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.03.012"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-022-08946-w"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13050851"},{"key":"e_1_2_11_4_2","article-title":"Renal Disease and Systemic Sclerosis: An Update on Scleroderma Renal Crisis","author":"Cole A.","year":"2023","journal-title":"Clinical Reviews in Allergy and Immunology"},{"key":"e_1_2_11_5_2","article-title":"C5-Inhibition Therapy in SRC-TMA: Review","author":"Farrukh L.","year":"2023","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"e_1_2_11_6_2","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1007\/s00296-024-05689-z","article-title":"Targeting Complement Dysregulation: Eculizumab in Scleroderma Renal Crisis Management\u2014A Case-Based Review","volume":"44","author":"Toker Dincer Z.","year":"2024","journal-title":"Rheumatology International"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/2397198318758606"}],"container-title":["Case Reports in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crrh\/5033806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crrh\/5033806","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crrh\/5033806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:41:32Z","timestamp":1788795692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crrh\/5033806"}},"subtitle":[],"editor":[{"given":"Ankit","family":"Dhoundiyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crrh\/5033806"],"URL":"https:\/\/doi.org\/10.1155\/crrh\/5033806","archive":["Portico"],"relation":{},"ISSN":["2090-6889","2090-6897"],"issn-type":[{"value":"2090-6889","type":"print"},{"value":"2090-6897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5033806"}}