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We report a 33\u2010year\u2010old woman with anti\u2010Jo\u20101\u2010positive ASS with a dermatomyositis phenotype and recurrent myositis despite multiple immunosuppressants, biologics, and Janus kinase (JAK) inhibitors. Upadacitinib was increased from 15 to 30\u2009mg\/day during a flare, together with intravenous immunoglobulin and temporary prednisolone escalation. During follow\u2010up, upadacitinib was withdrawn twice for fertility treatment; both withdrawals were followed by disease flares, and disease control was restored after reintroduction. Prednisolone was ultimately discontinued. This repeated withdrawal\u2010rechallenge pattern suggests that dose\u2010escalated upadacitinib may have contributed to sustained disease control.<\/jats:p>","DOI":"10.1155\/crrh\/5972090","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:16:57Z","timestamp":1789643817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dose\u2010Escalated Upadacitinib for Refractory Myositis in Anti\u2010Jo\u20101\u2010Positive Antisynthetase Syndrome: A Case 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