{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:14:08Z","timestamp":1780478048830,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":153,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Idiopathic inflammatory myopathies are, in some cases, refractory to all guideline\u2010based treatments, posing a very difficult challenge in clinical practice. Janus kinase inhibitors are a rather new class of disease\u2010modifying antirheumatic drugs that are approved for the treatment of rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis, but have been used as an off\u2010label treatment only in a very limited number of cases in inflammatory myopathies. In this case report, we present a middle\u2010aged woman with severe muscle weakness and pain attributed to refractory myositis associated with anti\u2010Jo\u20101 antibody. Despite multiple treatment attempts, which included all guideline\u2010based immunosuppressants, the patient\u2019s condition remained unresponsive. Initiation of tofacitinib therapy resulted in significant clinical improvement, normalization of creatinine kinase levels, and being possible to discontinue glucocorticoids. Our findings highlight the potential efficacy of tofacitinib in refractory inflammatory myopathies, and to our knowledge, our case is the first one to demonstrate the efficacy of a Janus kinase inhibitor in anti\u2010Jo\u20101 positive myopathy without interstitial lung disease.<\/jats:p>","DOI":"10.1155\/crrh\/6478835","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:32:56Z","timestamp":1780475576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Treatment of Anti\u2010Jo\u20101 Positive Inflammatory Myopathy With Tofacitinib"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0858-0412","authenticated-orcid":false,"given":"Janis","family":"Timsans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5448-5080","authenticated-orcid":false,"given":"Anna-Mari","family":"Hokkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0332-273X","authenticated-orcid":false,"given":"Joonas","family":"Rautavaara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2257-3291","authenticated-orcid":false,"given":"Anne","family":"Kerola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-7921","authenticated-orcid":false,"given":"Sanna","family":"Huovinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-734X","authenticated-orcid":false,"given":"Markku","family":"Kauppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv192"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww125"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0934"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000434"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2507-4"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211751"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000784"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac115"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000002010"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1158768"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.585761"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152474"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/hxin6o"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008128"}],"container-title":["Case Reports in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crrh\/6478835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crrh\/6478835","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crrh\/6478835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:32:59Z","timestamp":1780475579000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crrh\/6478835"}},"subtitle":[],"editor":[{"given":"Anjali","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crrh\/6478835"],"URL":"https:\/\/doi.org\/10.1155\/crrh\/6478835","archive":["Portico"],"relation":{},"ISSN":["2090-6889","2090-6897"],"issn-type":[{"value":"2090-6889","type":"print"},{"value":"2090-6897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6478835"}}