{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:19:10Z","timestamp":1787908750183,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":239,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Childhood\u2010onset Takayasu arteritis is rare, and data on outcomes beyond two or 3\u2009decades are exceptionally limited. We report one of the longest documented follow\u2010up observations of childhood\u2010onset Takayasu arteritis, spanning more than 4\u2009decades. The disease began at 9\u2009years of age, and the patient was diagnosed with morphologically confirmed Type III Takayasu arteritis at the age of 16\u2009years. She underwent renal vascular angioplasty and prosthetic reconstruction of the abdominal aorta for left renal artery occlusion associated with severe renovascular hypertension. In 2010, progression of supraaortic vascular disease required aortocarotid bypass surgery, followed six months later by left nephrectomy for persistent severe hypertension. Long\u2010term medical management included individualized intermittent treatment with low\u2010dose prednisolone and methotrexate. Despite extensive vascular involvement, the clinical course was characterized by gradual stabilization, progressively longer periods of clinical stability, and preservation of functional independence. Recent laboratory findings demonstrated only mild elevations in inflammatory markers, while vascular imaging showed chronic extensive arterial lesions with well\u2010developed collateral circulation, preserved cardiac function, and preserved function of the solitary right kidney. The favorable long\u2010term course was likely multifactorial, reflecting staged vascular reconstruction, individualized medical management, and adaptive collateral circulation. This case provides rare insight into the long\u2010term evolution and management of severe childhood\u2010onset Takayasu arteritis.<\/jats:p>","DOI":"10.1155\/crrh\/6725765","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:27:26Z","timestamp":1787905646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Childhood\u2010Onset Takayasu Arteritis With Extensive Vascular Involvement: A Four\u2010Decade Follow\u2010Up Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6850-465X","authenticated-orcid":false,"given":"Naylya","family":"Djumaeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnara","family":"Achundjanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Djumaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.125.076308"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01922-1"},{"key":"e_1_2_8_3_2","first-page":"129","article-title":"A Case of aorto-arteritis, Simulating Bechterev\u2032s Disease","volume":"60","author":"Gordowskaya N. 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