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Known risk factors for pseudogout include age, previous surgery, trauma, metabolic conditions, and medications. Isotretinoin, a retinoid frequently used to control acne vulgaris, is known to cause arthralgia, arthritis, and myalgia. We describe a case of an adolescent using isotretinoin who presented with acute left upper extremity pain and weakness. Birefringent calcium pyrophosphate dihydrate crystals were seen on synovial fluid analysis. The patient\u2019s symptoms resolved after discontinuing isotretinoin. This is the first reported case of pseudogout in an adolescent on isotretinoin.<\/jats:p>","DOI":"10.1155\/crrh\/7179310","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:24:27Z","timestamp":1771043067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case of Pseudogout in an Adolescent on Isotretinoin"],"prefix":"10.1155","volume":"2026","author":[{"given":"Toshihide","family":"Kuroe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayyaba","family":"Wajih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7923-5888","authenticated-orcid":false,"given":"Narihan","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-2883","authenticated-orcid":false,"given":"Lily Q.","family":"Lew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.139105"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1511117"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.22514\/jofph.2025.004"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2021.101718"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.12464"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.33181\/11062"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24619"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/oarrr.s389664"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720x11432559"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-023-01106-9"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900099"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf01451057"},{"key":"e_1_2_9_13_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5606\/ArchRheumatol.2017.6015","article-title":"Calcium Pyrophosphate Dihydrate Deposition Disease in Young Patients: Two Case Reports","volume":"32","author":"Wickrematilake G. 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