{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:51:11Z","timestamp":1787997071784,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Catastrophic antiphospholipid syndrome (CAPS) is a rare, life\u2010threatening variant of antiphospholipid syndrome (APS) characterized by rapid, widespread thrombosis leading to multiorgan failure. Affecting less than 1% of APS patients, CAPS is associated with a high mortality rate of 30%\u201350%, necessitating prompt diagnosis and aggressive treatment. The mainstay of management includes anticoagulation, high\u2010dose glucocorticoids, and plasma exchange or intravenous immunoglobulins, with biologic therapies such as rituximab and eculizumab reserved for refractory cases. We report a case of a 60\u2010year\u2010old male with a history of triple\u2010antibody\u2013positive APS complicated by recurrent diffuse alveolar hemorrhage (DAH), adrenal hemorrhage, chronic kidney disease, and superficial vein thrombosis. His condition progressed to CAPS approximately 5\u2009years prior with a course complicated by heparin\u2010induced thrombocytopenia. His condition stabilized with high\u2010dose corticosteroids and rituximab therapy with sustained symptomatic improvement after 10\u2009months of rituximab. This case highlights the complexity of CAPS diagnosis and management, in the context of DAH, emphasizing the importance of early recognition, multidisciplinary care, and individualized treatment strategies. Our patient\u2019s prolonged disease stabilization with rituximab underscores its potential role in long\u2010term CAPS management. Further research is needed to refine treatment protocols and improve outcomes for this rare but life\u2010threatening condition.<\/jats:p>","DOI":"10.1155\/crrh\/8852169","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:49:07Z","timestamp":1772959747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Catastrophic Antiphospholipid Syndrome: A Rare but Life\u2010Threatening Thrombotic Storm\u2014A Case Report and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9333-1123","authenticated-orcid":false,"given":"Renee","family":"Morecroft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-3567","authenticated-orcid":false,"given":"Jordan","family":"Phillipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-4399","authenticated-orcid":false,"given":"Vikas","family":"Majithia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1015-1633","authenticated-orcid":false,"given":"Sehreen","family":"Mumtaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.09.010"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.025759"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2024000544"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199805000-00005"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199805000-00005"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2025.24025"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.07.001"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.05.004"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2022.103055"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.10.004"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/antib13010021"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.02.007"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS25010668"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13947"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2023.152265"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1705454"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-015-8649-x"}],"container-title":["Case Reports in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crrh\/8852169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crrh\/8852169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crrh\/8852169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:49:08Z","timestamp":1772959748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crrh\/8852169"}},"subtitle":[],"editor":[{"given":"Anjali","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crrh\/8852169"],"URL":"https:\/\/doi.org\/10.1155\/crrh\/8852169","archive":["Portico"],"relation":{},"ISSN":["2090-6889","2090-6897"],"issn-type":[{"value":"2090-6889","type":"print"},{"value":"2090-6897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8852169"}}