{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:34:12Z","timestamp":1773786852387,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":344,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/10710-4"],"award-info":[{"award-number":["2022\/10710-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Veterinary Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Bacterial infections are common during the neonatal period, and sepsis is one of the main causes of mortality in dogs in the first 21 days. Maternal clinical and subclinical mastitis is one of the main sources of neonatal infection, leading to the ingestion of milk with bacteria and bacterial toxins, known as toxic milk syndrome. The objective of this report was to describe a case of neonatal sepsis in puppies secondary to maternal clinical mastitis, as well as its diagnosis and treatment. Three 5\u2010day\u2010old Pug dogs presented signs of neonatal infection: diarrhea, body erythema, and omphalitis. The bitch had purulent content in all of her breasts. Leukopenia due to neutropenia and monocytosis was observed in the puppies\u2032 blood count. The milk microbiological culture revealed\n                    <jats:italic>beta-hemolytic Streptococcus<\/jats:italic>\n                    , which was sensitive to antibiotics from the cephalosporin and penicillin classes according to the antibiogram. The puppies were separated from their mother, fed with breast milk substitute, and treated with ceftriaxone. The mother was treated with amoxicillin with potassium clavulanate. Neonatal and maternal infections were responsive to the antibiotics used, demonstrating the absence of signs of infection and blood counts without changes after 7 days of treatment. Early diagnosis and treatment were essential for the survival of the litter.\n                  <\/jats:p>","DOI":"10.1155\/crve\/6551231","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T10:21:51Z","timestamp":1765448511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal Sepsis in Dogs Caused by\n                    <i>Beta-Hemolytic Streptococcus<\/i>\n                    Sourced From Maternal Mastitis\u2014Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6474-4808","authenticated-orcid":false,"given":"Keylla Helena Nobre Pac\u00edfico","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8687-4135","authenticated-orcid":false,"given":"J\u00falia Cosenza","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3352-8261","authenticated-orcid":false,"given":"K\u00e1rita","family":"da Mata Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-0602","authenticated-orcid":false,"given":"Gleice Mendes","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9873-7419","authenticated-orcid":false,"given":"Diogo Ribeiro","family":"C\u00e2mara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4721-1801","authenticated-orcid":false,"given":"Fabiana Ferreira","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8337-4168","authenticated-orcid":false,"given":"Maria Lucia Gomes","family":"Louren\u00e7o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-49-S1-S2"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2009.03.010"},{"key":"e_1_2_13_3_2","first-page":"1","article-title":"Puppy Morbidity and Mortality Among Breeding Kennels in Nairobi, Kenya","volume":"1","author":"Konde A. M.","year":"2015","journal-title":"Jacobs Journal of Veterinary Science and Research."},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2017.05.005"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2021.10.015"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12329"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-1795-y"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.12834\/VetIt.45.2244.2"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani12233426"},{"key":"e_1_2_13_10_2","unstructured":"Lopez-QuintanaA. Ten Tips for Successfully Treating Sepsis. World Small Animal Veterinary Association World Congress Proceedings 2015 465\u2013468 https:\/\/www.vin.com\/apputil\/content\/defaultadv1.aspx?pId=14365%26catId=73680%26id=7259206. Accessed 15 Jan 2025."},{"key":"e_1_2_13_11_2","unstructured":"Montealegre-GolcherE. Surviving Sepsis in Veterinary Medicine 2018 https:\/\/www.isvma.org\/wp-content\/uploads\/2018\/10\/SurvivingsepsisinVeterinaryMedicine.pdf. Accessed 05 Jan 2025."},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155543"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani14233417"},{"key":"e_1_2_13_14_2","first-page":"33","article-title":"New Insights of Canine Mastitis\u2014A Review","volume":"36","author":"Kaszak I.","year":"2018","journal-title":"Animal Science Papers and Reports"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2023.110678"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1345933"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0450.2003.00672.x"},{"key":"e_1_2_13_18_2","first-page":"415","article-title":"Perinatal Mortality in Dogs. Clinical, Bacteriological and Pathological Studies","volume":"18","author":"Sager M.","year":"1990","journal-title":"Tierarztliche Praxis"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13147"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.21451\/1809-3000.RBRA2023.005"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2005.12.002"},{"key":"e_1_2_13_22_2","volume-title":"Bacterial Infections. Small Animal Pediatrics","author":"Daniels J.","year":"2011"}],"container-title":["Case Reports in Veterinary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crve\/6551231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crve\/6551231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crve\/6551231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:56:59Z","timestamp":1773773819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crve\/6551231"}},"subtitle":[],"editor":[{"given":"Lipi","family":"Buch","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crve\/6551231"],"URL":"https:\/\/doi.org\/10.1155\/crve\/6551231","archive":["Portico"],"relation":{},"ISSN":["2090-7001","2090-701X"],"issn-type":[{"value":"2090-7001","type":"print"},{"value":"2090-701X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6551231"}}