{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T04:37:26Z","timestamp":1777178246336,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":114,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62373056"],"award-info":[{"award-number":["62373056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62206165"],"award-info":[{"award-number":["62206165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Patients with facial synkinesis (FS) comorbid depression may experience aggravated symptoms of perceived synkinesis and poorer recovery outcomes. Exploring imaging features associated with depressive symptoms could help us better understand disease conditions and formulate appropriate rehabilitation plans. Although abnormal activation in the middle frontal gyrus (MFG) has been reported in depression patients, whether it represents an imaging correlate of depressive symptoms in patients with FS is still unknown. Therefore, a total of 52 participants (20 normal controls [NCs], 32 patients) with both task and resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) data were included in this study. Comorbid depression was assessed with the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM\u2010V), and depressive symptom severity was measured with the Beck Depression Inventory\u2010II (BDI\u2010II). We investigated brain activation during motor tasks (smiling, blinking, and grinning). In addition, the seed\u2010based functional connectivity (FC) between the MFG and other brain areas was calculated in the resting state. Additionally, we analyzed the associations between brain activity and clinical scale scores. The results revealed reduced activation in the sensorimotor and MFG during affected side movements across all tasks (voxel\u2010level\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05, cluster\u2010level\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05, Gaussian random field [GRF]\u2010corrected). Moreover, seed\u2010based FC between the MFG and emotion\u2010related areas was increased (voxel\u2010level\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05, cluster\u2010level\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05, GRF\u2010corrected), indicating impaired emotional networks in patients. Scores on the BDI\u2010II were negatively associated with MFG activation during tasks (R\u2009=\u2009\u22120.318,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.027) and positively associated with the FC of the MFG (\n                    <jats:italic>R<\/jats:italic>\n                    \u2009=\u20090.387,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.029). Thus, the MFG activation and connectivity may represent an increased risk for elevated depressive symptoms in patients with FS, warranting further validation in future studies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    Chinese Clinical Trial Registry: ChiCTR1800014630.\n                  <\/jats:p>","DOI":"10.1155\/da\/1705507","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T04:25:12Z","timestamp":1777177512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression"],"prefix":"10.1155","volume":"2026","author":[{"given":"Haonan","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2442-0478","authenticated-orcid":false,"given":"Zhilin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-3575","authenticated-orcid":false,"given":"Wei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-3683","authenticated-orcid":false,"given":"Jiehui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpsam.2023.0291"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7619"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1075840"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2021.04.007"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2011.01293.x"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2024.02.462"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2025.04.013"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.031"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2024.07.001"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44220-024-00248-8"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-06321-x"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.09.001"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03292-1"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsac003"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.235304"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhad390"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1019554"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2019.2938111"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.06.013"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-018-2050-x"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac029"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24381"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpsam.2023.0119"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2020.1773396"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.313055"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.07.026"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.11.036"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21399"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.008"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.04.019"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adr3675"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06541-3"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49600-7"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2014.04.012"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25263"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.06.001"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.010"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200411000-00026"},{"key":"e_1_2_13_40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