{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:19:25Z","timestamp":1790021965307,"version":"4.0.1"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071531"],"award-info":[{"award-number":["82071531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH124"],"award-info":[{"award-number":["ZR2024MH124"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Previous studies have documented brain structural changes in major depressive disorder with suicidal ideation (MDDSI). While sex differences in brain structure have been observed in MDD, the specific differences in MDDSI remain underexplored. This study aims to examine sex\u2010specific cortical structural changes in MDDSI patients, with the goal of improving suicide risk assessment and supporting the development of sex\u2010specific interventions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    High\u2010resolution T1\u2010weighted magnetic resonance imaging (MRI) data were acquired from 177 participants, including 117 patients with MDD (44 males and 73 females) and 60 healthy controls (HC; 23 males and 37 females). Using FreeSurfer, we assessed the main effects of both group and sex, as well as sex\u2010by\u2010group interactions, on cortical thickness (CT), surface area (SA), cortical volume (CV), and local gyrification index (LGI). Pearson partial correlation analysis was performed to examine the associations between sex\u2010specific regions and SI scores.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Patients with MDDSI exhibited significantly reduced LGI in the right inferior and superior parietal cortices, irrespective of sex. Significant sex\u2010by\u2010group interactions were identified and post hoc analyses revealed that male MDDSI patients showed significantly greater CT in the right lingual gyrus (LG) compared to their female counterparts, along with smaller SA in the right lateral occipital cortex (LOC) and reduced CV in the right pericalcarine cortex (PCAL) compared to their sex\u2010matched MDD patients without SI (MDDNonSI). No significant associations were found between these structural changes and SI scores.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    This study highlights sex\u2010specific differences in cortical structures in MDDSI patients. These findings contribute to understanding the neurobiological mechanisms underlying MDD with SI.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    Chinese Clinical Trial Registry (ChiCTR): ChiCTR2100049646\n                  <\/jats:p>","DOI":"10.1155\/da\/1706750","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:48:53Z","timestamp":1751431733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sex Differences in Cortical Structural Alterations in Major Depressive Disorder With Suicidal Ideation"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8680-6405","authenticated-orcid":false,"given":"Jiayi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6767-3638","authenticated-orcid":false,"given":"Hongyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4317-6747","authenticated-orcid":false,"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3983-372X","authenticated-orcid":false,"given":"Wu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6305-9448","authenticated-orcid":false,"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4167-7859","authenticated-orcid":false,"given":"Xiaochi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3368-654X","authenticated-orcid":false,"given":"Cong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6735-1938","authenticated-orcid":false,"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-3615","authenticated-orcid":false,"given":"Jingjing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5956-8086","authenticated-orcid":false,"given":"Jian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_13_1_2","unstructured":"World Health Organization Depressive Disorder (Depression) 2023."},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.690130"},{"key":"e_1_2_13_4_2","volume-title":"Suicidal Ideation","author":"Harmer B.","year":"2024"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001547"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-021815-093204"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.08.106"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(21)00395-3"},{"key":"e_1_2_13_9_2","first-page":"22","article-title":"Sex Difference in Incidence of Major Deprssive Disorder: An Analysis From the Global Burden of Disease Study 2019","volume":"2019","author":"Li S. 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