{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:11:52Z","timestamp":1784117512398,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":195,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006378","name":"Universitas Indonesia","doi-asserted-by":"publisher","award":["NKB-351\/UN2.RST\/HKP.05.00\/2023"],"award-info":[{"award-number":["NKB-351\/UN2.RST\/HKP.05.00\/2023"]}],"id":[{"id":"10.13039\/501100006378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anxiety is a prevalent issue among cancer patients undergoing chemotherapy, significantly impacting their treatment and quality of life. Virtual reality (VR) has emerged as a promising nonpharmacological intervention to reduce anxiety by providing immersive, distraction\u2010based experiences. This study introduces a VR application featuring the Seribu Islands, designed to alleviate anxiety through exposure to natural environments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effectiveness of the VR Seribu Island in reducing anxiety, evaluate user experience (UX), and identify potential cybersickness symptoms among healthy participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A mixed\u2010methods design was used to evaluate 30 healthy participants who interacted with the VR Seribu Island. Pre and Postexposure anxiety levels were measured using the State\u2013Trait Anxiety Inventory (STAI). UX was assessed via a questionnaire, and semi\u2010structured interviews explored participant perceptions. Cybersickness symptoms were evaluated using the Cybersickness Syndrome Questionnaire (CSQ\u2010VR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Post\u2010VR anxiety scores were significantly lower than pre\u2010VR scores (median difference\u2009=\u20098.0, 95% CI [4.39, 8.61],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.83), indicating a reduction in anxiety. Participants reported high satisfaction with the VR experience, with an average score of 4.48 out of 5. Cybersickness symptoms were minimal, with low severity reported across most metrics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The VR Seribu Island significantly reduced anxiety and was well received by participants. This preliminary study supports further investigation of VR as a therapeutic tool for anxiety management in clinical populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/da\/3317133","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:45:38Z","timestamp":1784115938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Virtual Reality for Anxiety Reduction: A Mixed\u2010Methods Preliminary Study on Blue Space Environments Among Healthy Participants"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-5683","authenticated-orcid":false,"given":"Adisti","family":"Dwijayanti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-985X","authenticated-orcid":false,"given":"Aida Rosita","family":"Tantri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0828-3354","authenticated-orcid":false,"given":"Dina","family":"Muktiarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1438-096X","authenticated-orcid":false,"given":"Imelda Rosalyn","family":"Sianipar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6612-5171","authenticated-orcid":false,"given":"Uti Nilam","family":"Sari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5440-8736","authenticated-orcid":false,"given":"Natalia Widiasih","family":"Raharjanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-615X","authenticated-orcid":false,"given":"Rima Maulida","family":"Hidayati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7451-546X","authenticated-orcid":false,"given":"Minhua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_10_1_2","unstructured":"WHO Cancer 2020 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer."},{"key":"e_1_2_10_2_2","unstructured":"International Agency for Research on Cancer Cancer Tomorrow 2020 https:\/\/gco.iarc.fr\/tomorrow\/en."},{"key":"e_1_2_10_3_2","unstructured":"Global Cancer Observatory 360-Indonesia-Fact-Sheets 2021 https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/360-indonesia-fact-sheets.pdf."},{"key":"e_1_2_10_4_2","unstructured":"Ministry of Health of the Republic of Indonesia and Directorate General of Disease Prevention and Control Penyakit Kanker di Indonesia Berada Pada Urutan 8 di Asia Tenggara Dan Urutan 23 di Asia [Cancer in Indonesia Ranks 8th in Southeast Asia and 23rd in Asia] [In Indonesian] 2019 http:\/\/p2p.kemkes.go.id\/penyakit-kanker-di-indonesia-berada-pada-urutan-8-di-asia-tenggara-dan-urutan-23-di-asia\/."},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245987"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/da.23059"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2793-5"},{"key":"e_1_2_10_8_2","first-page":"167","article-title":"Prevalence of Depression and Anxiety Among Cancer Patients","volume":"5","author":"Nikbakhsh N.","year":"2014","journal-title":"Caspian Journal of Internal Medicine"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.25919"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8414"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24954"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3928\/02793695-20160725-07"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.675"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29422"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pan3.10620"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000599"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/g4h.2015.0046"},{"key":"e_1_2_10_18_2","unstructured":"Meta Get Started With Meta Quest 2 2022 https:\/\/www.meta.com\/ca\/quest\/products\/quest-2\/."},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951521002017"},{"key":"e_1_2_10_20_2","volume-title":"Manual for the State-Trait Anxiety Inventory (Form Y)","author":"Spielberger C. 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