{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:51:33Z","timestamp":1791280293853,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":240,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Major depressive disorder (MDD) has become one of the diseases that seriously affects the quality of life and social function of patients. Electroconvulsive therapy (ECT) is an important method for treating mental disorders. This study aims to conduct a comparison of symptomatic improvement in patients with MDD across different age groups following ECT, thereby providing more precise and personalized treatment plans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Cochrane Library, CNKI, Wanfang, and other databases were searched for related studies from self\u2010built databases until February 2025. The retrieved studies were then subjected to a meta\u2010analysis using R software. Based on the assessment of heterogeneity across studies, either a fixed\u2010effect model or a random\u2010effect model was selected for data synthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 15 eligible articles were included in this meta\u2010analysis, involving 1617 patients with MDD. The results indicated ECT could reduce the scores of the Hamilton Depression Rating Scale (HAMD), Montgomery\u2013\u00c5sberg Depression Rating Scale (MADRS), and Hamilton Anxiety Rating Scale (HAMA). Additionally, it could increase the scores of the Mini\u2010Mental State Examination (MMSE). However, no statistical significance was observed on the subscales of the Wechsler Memory Scale (WMS). Subgroup analysis and meta\u2010regression revealed that the older patients (&gt;60 years old) may benefit more significantly in improving depressive symptoms (HAMD and MADRS) and WMS recognition memory. No significant age\u2010related differences are observed in HAMA, MMSE, or other WMS subtests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ECT demonstrates therapeutic effects across all age groups of patients with MDD. The older group seemed to benefit more from this treatment modality compared to other age groups. These findings contribute to a better understanding of the differential effects of ECT in patients with MDD of different ages, which may guide clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/da\/4345722","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:44:27Z","timestamp":1787996667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Therapeutic Effect of Electroconvulsive Therapy on Depressive Patients of Different Ages: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1169-3228","authenticated-orcid":false,"given":"Chifai","family":"Tam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3553-5967","authenticated-orcid":false,"given":"Lingling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9293-6417","authenticated-orcid":false,"given":"Haohao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1622-1081","authenticated-orcid":false,"given":"Ying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-2465","authenticated-orcid":false,"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.05.003"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l1079"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.6633.1"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2024.103998"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.1378"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/yct.0000000000000135"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2034954"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2017.28"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14r09528"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2024.09.013"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.02.053"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2022.20.1.1"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.6133"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S394155"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.06.052"},{"key":"e_1_2_13_16_2","unstructured":"WangH. Effectiveness and Cognitive Change Following Electroconvulsive Therapy Among Adolescents and Young Adults With Depression 2022 Guangzhou Medical University Guangzhou China M.S. thesishttps:\/\/doi.org\/10.27043\/d.cnki.ggzyc.2022.000264."},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.11.014"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.11.064"},{"key":"e_1_2_13_19_2","unstructured":"ZhangQ. Curative Effect Comparison of Different Periodical Modified Electroconvulsive Therapy of Patients With Treatment-Resistant Depression 2018 North China University of Science and Technology Tangshan China M.S. Thesis."},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.19368\/j.cnki.2096-1782.2017.10.027"},{"key":"e_1_2_13_21_2","article-title":"Exploring the Clinical Efficacy and Safety of Non-Voluntary Electroconvulsive Therapy in the Treatment of Elderly Patients With Refractory Depression","volume":"41","author":"Liang X.","year":"2017","journal-title":"Health Guide"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.140322"},{"key":"e_1_2_13_23_2","article-title":"Clinical Study of Modified Electroconvulsive Therapy for Refractory Late-Life Depression","volume":"29","author":"Xie Q.","year":"2016","journal-title":"Journal of Psychiatry"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.13361\/j.qdyxy.201501015"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.13406\/j.cnki.cyxb.2011.03.028"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.02.131"},{"key":"e_1_2_13_27_2","article-title":"Observation on 44 Cases of Elderly Depression Treated With Non-Convulsive Electroconvulsive Therapy","volume":"22","author":"Xu S.","year":"2009","journal-title":"Journal of Psychiatry"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.06.009"},{"key":"e_1_2_13_29_2","first-page":"185","article-title":"Research Progress on the Mechanism of Electroconvulsive Therapy for Depression","volume":"3","author":"Cao L.","year":"2015","journal-title":"Journal of Jining Medical University"},{"key":"e_1_2_13_30_2","first-page":"289","article-title":"Application Status of Modified Electroconvulsive Therapy in Adolescents With Mood","volume":"25","author":"Wang S.","year":"2025","journal-title":"Journal of Neuroscience and Mental Health"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/s24237565"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/da\/4345722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/da\/4345722","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/da\/4345722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:59:42Z","timestamp":1791277182000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/da\/4345722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/da\/4345722"],"URL":"https:\/\/doi.org\/10.1155\/da\/4345722","archive":["Portico"],"relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4345722"}}