{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:51:21Z","timestamp":1787986281918,"version":"build-2784847793"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":329,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Major depressive disorder (MDD) is common and associated with high social and economic burden. Knowledge of characteristics of hospitalized adults with MDD can help identify clinical treatment and prevention targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The multicenter \u201cPatient Characteristics, Validity of Clinical Diagnoses and Outcomes Associated with Suicidality in Inpatients with Symptoms of Depression\u201d (OASIS\u2010D) study assessed characteristics of patients aged 18\u201375\u2009years hospitalized between October 2020 and December 2024, who were admitted to a psychiatric inpatient unit for MDD at eight German centers. Baseline illness\u2010, treatment\u2010, and suicidality\u2010related characteristics of the overall sample are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 3795 patients (median age\u2009=\u200942.0, interquartile range [IQR]\u2009=\u200927.5\u201357.0\u2009years; females\u2009=\u200953.9%) with MDD (severe episode\u2009=\u200975.3%, psychotic features\u2009=\u20097.9%; first episode\u2009=\u200934.9%; treatment\u2010resistant depression [TRD]\u2009=\u200918.2%). Psychiatric comorbidities of MDD were present in 46.2% and included substance use disorder (18.9%), personality disorders (8.4%), stress\/adjustment disorders (7.6%), and phobic\/other anxiety disorders (6.6%). In 42.5%, the admission was prompted by a psychiatric emergency, primarily due to suicidality (35.0%), followed by stupor\/refusal\/intoxication\/acute agitation (0.9%\u20131.5%), or danger to others\/delirium (0.1%\u20130.3%). Overall, 72.0% of patients had active or passive suicidal thoughts, and 11.5% had attempted suicide within 2 weeks prior to admission. Furthermore, 83.9% had lifetime suicidal thoughts, and 36.0% had lifetime suicide attempts. Altogether, 76.8% had received outpatient psychiatric care within their lifetime (62.3% within 6 months), and 57.8% of patients had lifetime inpatient treatment for MDD. At admission, 71.6% of patients were prescribed psychiatric medications: antidepressants\u2009=\u200959.8%; antipsychotic\u2009=\u200925.1%, anxiolytics\/hypnotics\u2009=\u200911.8%, and mood stabilizers\u2009=\u20098.6%. Additionally, 4.0% had previously received electroconvulsive therapy (ECT). The median hospitalization duration was 31.0 (IQR\u2009=\u200913.0, 57.0) days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Almost half of admissions in adults with MDD were considered emergencies, with 90% being related to suicidality, and only &lt;60% received antidepressants at admission. These data underscore the need for early identification and treatment of adults with MDD, especially those with suicidality. Outcomes of this population required further study.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT04404309\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/da\/4470169","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:35:52Z","timestamp":1764221752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Treatment Characteristics of 3795 Adults Consecutively Hospitalized for Major Depressive Disorder in the OASIS\u2010D Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6083-8468","authenticated-orcid":false,"given":"Viktor B.","family":"N\u00f6hles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-6328","authenticated-orcid":false,"given":"Felix","family":"Bermpohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-3428","authenticated-orcid":false,"given":"Nikola","family":"Schoofs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-0273","authenticated-orcid":false,"given":"Rouven","family":"Bathe-Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2550-5186","authenticated-orcid":false,"given":"Nina","family":"Hilpert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-9208","authenticated-orcid":false,"given":"Forugh Salimi","family":"Dafsari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Reif-Leonhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Schillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8053-0162","authenticated-orcid":false,"given":"Rabia Sana","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Getty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-8667","authenticated-orcid":false,"given":"Peter","family":"Falkai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Sch\u00fcle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Adli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Papenfu\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meyer-Lindenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Fritze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Otte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Piber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Graumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Weyn-Banningh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2666-859X","authenticated-orcid":false,"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Lewitzka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-8520","authenticated-orcid":false,"given":"Maik","family":"Spreer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Rubarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7254-5646","authenticated-orcid":false,"given":"Christoph U.","family":"Correll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21243-x"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-90"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-022-04165-x"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S201567"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12301"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy009"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718002301"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674371405900303"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.113"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12195"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S19617"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-021-01019-4"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.5539\/res.v11n1p73"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796019000180"},{"key":"e_1_2_10_16_2","volume-title":"Nationale Versorgungs Leitlinie Unipolare Depression \u2013 Langfassung","author":"Bundes\u00e4rztekamme (B\u00c4K)","year":"2022"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12929"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(09)71017-X"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/08039488.2020.1764619"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-020-02781-z"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.10.069"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.07.025"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.16589"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.05.002"},{"key":"e_1_2_10_25_2","first-page":"419","article-title":"Risk of Suicide in Patients With Major Depressive Disorder and Comorbid Chronic Pain Disorder: An Insight From National Inpatient Sample Data","volume":"25","author":"Jolly T.","year":"2022","journal-title":"Pain Physician"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.11.013"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/461265"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000503686"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/add.14866"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/00048674211025697"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-019-0248-0"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-022-02504-6"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.02.002"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/13651501.2011.638142"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v67n0814"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-019-2371-5"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1521\/pedi_2012_26_052"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.12.141"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05650blu"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/0706743720935647"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.21m03159"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2014.06.005"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0713"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12869"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004060070016"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.06.041"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10597-021-00889-4"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1721558"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-019-01038-5"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.795"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.3109\/00048679009077707"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.pn.2022.09.7.20"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-200606000-00010"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13425"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.3109\/13651501.2014.988272"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11126-018-9569-4"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.2196\/30827"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-023-05230-9"},{"key":"e_1_2_10_59_2","unstructured":"World Health Organization ICD-10: International Statistical Classification of Diseases and Related Health Problems: Tenth Revision 2004 2nd edition."},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815508"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-022-04500-2"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-019-0704-8"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2015.1014025"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20482"},{"key":"e_1_2_10_65_2","first-page":"723","volume-title":"MEDINFO 2017: Precision Healthcare Through Informatics","author":"H\u00e4gglund M.","year":"2017"},{"key":"e_1_2_10_66_2","volume-title":"Agency for Healthcare Research and Quality (US)","author":"Reinhard S. C.","year":"2008"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201500439"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/da\/4470169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/da\/4470169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/da\/4470169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:45:16Z","timestamp":1772966716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/da\/4470169"}},"subtitle":[],"editor":[{"given":"Carlos","family":"Carona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/da\/4470169"],"URL":"https:\/\/doi.org\/10.1155\/da\/4470169","archive":["Portico"],"relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4470169"}}