{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:10:08Z","timestamp":1785406208354,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":210,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2321-B-006-014"],"award-info":[{"award-number":["NSTC 112-2321-B-006-014"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2321-B-006-015"],"award-info":[{"award-number":["NSTC 113-2321-B-006-015"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Generalized anxiety disorder (GAD) is marked by emotional dysregulation and impaired inhibitory control, often linked to atypical prefrontal cortex (PFC) function. However, how emotional context influences PFC engagement during inhibition remains unclear. This study aimed to examine how emotional versus nonemotional contexts modulate PFC activity in GAD compared to healthy controls (HCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Functional near\u2010infrared spectroscopy (fNIRS) assessed bilateral PFC activity in 23 individuals with GAD and 42 HC during emotional and nonemotional Go\/No\u2010Go tasks. Two\u2010way repeated\u2010measures ANOVAs (group\u2009\u00d7\u2009condition) were conducted per channel with false discovery rate (FDR) correction. Effect sizes are reported as partial eta squared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant group\u2009\u00d7\u2009condition interaction was found for No\u2010Go accuracy (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.032,\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sub>p<\/jats:sub>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.074), with GAD showing a larger decline from nonemotional to emotional conditions (87.70% vs. 47.17%) than HC (79.49% vs. 48.54%). For PFC activity, group\u2009\u00d7\u2009condition interactions reached uncorrected significance in the left dorsolateral PFC (DLPFC) and right dorsomedial PFC (DMPFC) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013\u20130.047,\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sub>p<\/jats:sub>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.061\u20130.094), and the group main effect was uncorrected significant across bilateral dorsomedial and dorsolateral PFC (DLPFC,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005\u20130.039,\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sub>p<\/jats:sub>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.066\u20130.130); neither survived FDR correction. Significant condition main effect in the right dorsomedial and right ventromedial PFC (VMPFC,\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sub>p<\/jats:sub>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.120\u20130.159) were revealed after FDR correction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both groups showed PFC deactivation under emotional load, most prominently in the right medial PFC. HC exhibited context\u2010dependent modulation of the left dorsolateral and right DMPFC, whereas GAD showed a flat, unmodulated response and broadly lower PFC activation, alongside selective impairment of response inhibition. These preliminary findings suggest prefrontal inflexibility as a core neural feature of GAD and underscore the role of left dorsolateral and DMPFC in emotion\u2013cognition integration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/da\/5533403","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:55:54Z","timestamp":1785405354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Prefrontal Hypoactivity in Generalized Anxiety Disorder: The Influence of Nonemotional and Emotional Stimuli in a Go\/No\u2010Go Task"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-2465","authenticated-orcid":false,"given":"Chien-An","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-8287","authenticated-orcid":false,"given":"Yi-Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8251-636X","authenticated-orcid":false,"given":"Hsiao-Ting","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pai-Yi","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Han","family":"Keng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-6648","authenticated-orcid":false,"given":"I-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-4744","authenticated-orcid":false,"given":"Yi-Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2244-8706","authenticated-orcid":false,"given":"Yu-Jui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-7414","authenticated-orcid":false,"given":"Pao-Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-5066","authenticated-orcid":false,"given":"Jia-Jin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/da.10065"},{"key":"e_1_2_9_2_2","first-page":"59","article-title":"[Neuropsychology of Generalized Anxiety Disorders: A Systematic Review]","volume":"69","author":"Langarita-Llorente R.","year":"2019","journal-title":"Revue Neurologique"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1352465800015897"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-050212-185544"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2009.11.003"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.06.041"},{"key":"e_1_2_9_7_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.102016","article-title":"Systematic Review and Meta-Analyses of Neural Structural and Functional Differences in Generalized Anxiety Disorder and Healthy Controls Using Magnetic Resonance Imaging","volume":"24","author":"Kolesar T. 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