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In adults and adolescents, family and peer criticism\/conflict and rejection sensitivity are associated with recurrence. However, it is not yet clear whether similar factors are associated with relapse among early adolescent youth who experience depression starting in preschool. The current study used data from a unique longitudinal study, which began at preschool age and included 161 youth. It oversampled for those with preschool\u2010onset major depressive disorder (PO\u2010MDD) and included community controls (CCs). When the youth were 7\u201312 years old, we administered diagnostic interviews and weekly surveys over 1 year. These measures were repeated at ages 8\u201315, along with ecological momentary assessment (EMA) three to four times a day for 8 days, and an event\u2010related potential (ERP) task assessing neural reactivity to social feedback. We assessed whether youth with a history of PO\u2010MDD who were experiencing depression in adolescence (i.e., non\u2010remitted youth [NRY]) versus those who were not (i.e., remitted youth [RY]) and\/or CCs experienced greater family\/peer criticism\/conflict and sensitivity to interpersonal stress. Across multiple time scales (weekly and daily), NRY experienced greater parent and peer criticism\/conflict and were more reactive to such criticism\/conflict than RY and CCs. Further, in weekly surveys, NRY displayed a stronger association between experiencing interpersonal criticism\/conflict and depression compared to CCs, with a similar trend compared to RY. In momentary assessments, NRY showed a longer\u2010lasting association between family conflict and both negative affect (NA) and connectedness than RY. In addition, neural measures indicated a stronger response to negative social feedback among NRY. Taken together, these data identify potential interpersonal treatment targets for youth with early\u2010onset depression who continue to experience depression into adolescence.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT02076425\n                  <\/jats:p>","DOI":"10.1155\/da\/5803578","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:47:16Z","timestamp":1785228436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reactivity to Interpersonal Conflict: A Correlate of Non\u2010Remission in Childhood Depression\u2014Evidence Across Modalities and Time Scales"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1693-8506","authenticated-orcid":false,"given":"Deanna 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