{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:05:31Z","timestamp":1787580331356,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Toludesvenlafaxine hydrochloride sustained\u2010release tablets, as China\u2019s first independently developed chemical Class 1 innovative drug with independent intellectual property rights for the treatment of depression and a new molecular entity, represent a novel triple reuptake inhibitor (TRI) with specific target selectivity for serotonin (5\u2010HT), norepinephrine (NE), and dopamine (DA). This single\u2010arm, multicenter clinical study aimed to evaluate the efficacy and safety of toludesvenlafaxine in alleviating anhedonia symptoms in patients with major depressive disorder (MDD). A total of 123 patients aged 18\u201365 years were enrolled between April 2023 and April 2024 and received an 8\u2010week treatment with toludesvenlafaxine sustained\u2010release tablets (80\u2013160\u2009mg\/day). The primary efficacy endpoint was the change in the total score of the Dimensional Anhedonia Rating Scale (DARS) at weeks 2, 4, and 8. Significant improvements in DARS scores were observed, with mean changes from baseline of 8.4 (95% CI [6.4, 10.4],\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001), 14.1 (95% CI [12.0, 16.2],\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001), and 20.4 (95% CI [18.0, 22.9],\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001), respectively. Additionally, after 8 weeks of treatment, plasma levels of neurotrophic factors, including mature brain\u2010derived neurotrophic factor (mBDNF) (\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u200928.78,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001), pro\u2010BDNF (\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u200927.71,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001), and vascular endothelial growth factor (VEGF) (\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u200931.07,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001), were significantly increased, and the plasma level of IGF\u20101 was not significantly changed (\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u20090.35,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.7269). No association was found between the percentage of changes in neurotrophic factors and the percentage of symptom improvements. Toludesvenlafaxine was generally well\u2010tolerated, with treatment\u2010emergent adverse events (AEs) (TEAEs) reported in 83.7% of participants and treatment\u2010related AEs (TRAEs) in 76.4%. These findings indicate that toludesvenlafaxine hydrochloride sustained\u2010release tablets are safe, well\u2010tolerated, and effective in alleviating anhedonia symptoms in patients with depression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\">http:\/\/www.chictr.org.cn<\/jats:ext-link>\n                    (No.: ChiCTR2300070331).\n                  <\/jats:p>","DOI":"10.1155\/da\/6130764","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T03:33:58Z","timestamp":1746502438000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained\u2010Release Tablets in Depression With Anhedonia: A Single\u2010Arm, Multicenter 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