{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:45:56Z","timestamp":1789821956232,"version":"4.0.1"},"reference-count":234,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008092","name":"Jinhua Science and Technology Bureau","doi-asserted-by":"publisher","award":["2024-3-022"],"award-info":[{"award-number":["2024-3-022"]}],"id":[{"id":"10.13039\/501100008092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51901160"],"award-info":[{"award-number":["51901160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY22H020005"],"award-info":[{"award-number":["LY22H020005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019014","name":"Chengdu Science and Technology Program","doi-asserted-by":"publisher","award":["2022-YF05-02018-SN"],"award-info":[{"award-number":["2022-YF05-02018-SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007958","name":"Wenzhou University","doi-asserted-by":"publisher","award":["3162024003057"],"award-info":[{"award-number":["3162024003057"]}],"id":[{"id":"10.13039\/501100007958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007958","name":"Wenzhou University","doi-asserted-by":"publisher","award":["3162024003056"],"award-info":[{"award-number":["3162024003056"]}],"id":[{"id":"10.13039\/501100007958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007958","name":"Wenzhou University","doi-asserted-by":"publisher","award":["3162024004102"],"award-info":[{"award-number":["3162024004102"]}],"id":[{"id":"10.13039\/501100007958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>The escalating global prevalence of type 2 diabetes mellitus (T2DM) and mental disorder (MD) including schizophrenia, bipolar disorder, major depressive disorder, and anxiety highlights the urgency for comprehensive therapeutic strategies. Aerobic exercise (AE) is a viable adjunct therapy, providing significant benefits for individuals dealing with both T2DM and MD. This review consolidates evidence on AE\u2019s role in alleviating the physiological and psychological effects of these comorbid conditions. It delves into the pathophysiological connections between T2DM and various MD, including depression, schizophrenia, anxiety, and bipolar disorder\u2014emphasizing their reciprocal exacerbation. Key neurophysiological mechanisms through which AE confers benefits are explored, including neuroinflammation modulation, brain structure and neuroplasticity enhancement, growth factor expression regulation, and hypothalamic\u2013pituitary\u2013adrenal (HPA)\/microbiota\u2013gut\u2013brain (MGB) axis normalization. Clinical results indicate that AE significantly improves both metabolic and psychological parameters in patients with T2DM and MD, providing a substantial argument for integrating AE into comprehensive treatment plans. Future research should aim to establish detailed, personalized exercise prescriptions and explore the long\u2010term benefits of AE in this population. This review underscores the potential of AE to complement existing therapeutic modalities and enhance the management of patients with T2DM and MD.<\/jats:p>","DOI":"10.1155\/da\/6651804","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T15:34:33Z","timestamp":1735659273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Aerobic Exercise Improves the Overall Outcome of Type 2 Diabetes Mellitus Among People With Mental Disorders"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8797-4606","authenticated-orcid":false,"given":"Jiaxuan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5120-9048","authenticated-orcid":false,"given":"Fan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9266-4794","authenticated-orcid":false,"given":"Peiye","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9999-2436","authenticated-orcid":false,"given":"Ting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9043-5097","authenticated-orcid":false,"given":"Baihui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaikai","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinsi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-9951","authenticated-orcid":false,"given":"Da","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0096-0160","authenticated-orcid":false,"given":"Xia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.203"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2152"},{"key":"e_1_2_12_3_2","article-title":"IDF Diabetes Atlas: Global, Regional and Country-Level Diabetes Prevalence Estimates for 2021 and Projections for 2045","volume":"204","author":"Sun H.","year":"2023","journal-title":"Diabetes Research and Clinical Practice"},{"key":"e_1_2_12_4_2","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.615048","article-title":"Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment","volume":"12","author":"Li C.","year":"2020","journal-title":"Frontiers In Aging Neuroscience"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13893"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-0177"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1874-x"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796016000949"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01338-2"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.1702"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-012-9377-2"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2022.108185"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145721714538925"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-24"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212310"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0347-4"},{"key":"e_1_2_12_17_2","first-page":"255","article-title":"Effects of Regular Physical Activity on the Cognitive Performance of Type 2 Diabetic Patients: A Systematic Review","volume":"16","author":"Shellington E. M.","year":"2018","journal-title":"Metabolic Syndrome and Related Disorders"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119129"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp18X695381"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.06.028"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415617657"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.0534"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2012-091287"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6597"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2018.07.004"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.12.020"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v9.i2.134"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2017.04.007"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12581"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44242-7"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-016-1481-5"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181515"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.06.008"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-019-01187-6"},{"key":"e_1_2_12_35_2","first-page":"15","article-title":"Exercise for the Treatment of Depression and Anxiety","volume":"41","author":"Carek P. J.","year":"2011","journal-title":"International Journal of Sports Medicine"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010140"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2018.02.032"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00906"},{"key":"e_1_2_12_39_2","first-page":"46","article-title":"The Pathogenesis and Pathophysiology of Type 1 and Type 2 Diabetes Mellitus","volume":"4","author":"Ozougwu O. K. C.","year":"2013","journal-title":"JPAP"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2019.01.040"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.09.003"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105909"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105840"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07455"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.12.017"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr253"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2016.1105217"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.05.018"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0304-6"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0473-x"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170125"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709992285"},{"key":"e_1_2_12_53_2","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0165-0327(12)70004-6","article-title":"Epidemiology of Depression and Diabetes: A Systematic Review","volume":"142","author":"Roy T.","year":"2012","journal-title":"Journal of Affective Disorders"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.6.1069"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7110445"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01295-9"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.09.008"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.11.1631"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15020152"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031616"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120433"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00343"},{"key":"e_1_2_12_63_2","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/164760","article-title":"Comorbidity between Type 2 Diabetes and Depression in the Adult Population: Directions of the Association and Its Possible Pathophysiological Mechanisms","volume":"2015","author":"Berge L. I.","year":"2015","journal-title":"International Journal of Endocrinology"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.08.008"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.10.001"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1168-8"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071811-150648"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.04.001"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102081"},{"key":"e_1_2_12_70_2","article-title":"Advances in Zebrafish as a Comprehensive Model of Mental Disorders","volume":"2023","author":"Chaoul V.","year":"2023","journal-title":"Depression and Anxiety"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32835035ca"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-018359"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs082"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066299"},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06801"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.07.001"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2019.08.012"},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.3"},{"key":"e_1_2_12_79_2","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s00213-015-3975-1","article-title":"Is There a Role for Immune-to-Brain Communication in Schizophrenia?","volume":"233","author":"Khandaker G. M.","year":"2016","journal-title":"Psychopharmacology"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.01.014"},{"key":"e_1_2_12_81_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13712"},{"key":"e_1_2_12_82_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S392672"},{"key":"e_1_2_12_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60827-1"},{"key":"e_1_2_12_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnss.2019.09.003"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-022-04494-x"},{"key":"e_1_2_12_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2012.11.013"},{"key":"e_1_2_12_87_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.1\/bpenninx"},{"key":"e_1_2_12_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.147045"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.357"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13217"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160922165706"},{"key":"e_1_2_12_92_2","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0931"},{"key":"e_1_2_12_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.03.020"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02678-2"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.01.047"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.03.007"},{"key":"e_1_2_12_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3822"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00546"},{"key":"e_1_2_12_99_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14020148"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2015.07.008"},{"key":"e_1_2_12_101_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-017-0179-x"},{"key":"e_1_2_12_102_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-021-01875-x"},{"key":"e_1_2_12_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.10.006"},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2019.1550361"},{"key":"e_1_2_12_105_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2019.1659511"},{"key":"e_1_2_12_106_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-016-0054-4"},{"key":"e_1_2_12_107_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00501"},{"key":"e_1_2_12_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpsy.2021.11.002"},{"key":"e_1_2_12_109_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200721010-00001"},{"key":"e_1_2_12_110_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00314.2018"},{"key":"e_1_2_12_111_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12414"},{"key":"e_1_2_12_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.08.058"},{"key":"e_1_2_12_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2019.07.001"},{"key":"e_1_2_12_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.03.004"},{"key":"e_1_2_12_115_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-010-3207-1"},{"key":"e_1_2_12_116_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182088"},{"key":"e_1_2_12_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.04.057"},{"key":"e_1_2_12_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.03.014"},{"key":"e_1_2_12_119_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187119"},{"key":"e_1_2_12_120_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ18-0579"},{"key":"e_1_2_12_121_2","doi-asserted-by":"publisher","DOI":"10.1590\/1980-549720190023"},{"key":"e_1_2_12_122_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871527313666140612102841"},{"key":"e_1_2_12_123_2","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2019-002491"},{"key":"e_1_2_12_124_2","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1007\/s12035-018-1195-5","article-title":"Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models","volume":"56","author":"Rom S.","year":"2019","journal-title":"Molecular Neurobiology"},{"key":"e_1_2_12_125_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22116138"},{"key":"e_1_2_12_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.002"},{"key":"e_1_2_12_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115807"},{"key":"e_1_2_12_128_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00271"},{"key":"e_1_2_12_129_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052810"},{"key":"e_1_2_12_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.06.021"},{"key":"e_1_2_12_131_2","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2022.122"},{"key":"e_1_2_12_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2008.06.005"},{"key":"e_1_2_12_133_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01307"},{"key":"e_1_2_12_134_2","doi-asserted-by":"publisher","DOI":"10.1042\/bse0420105"},{"key":"e_1_2_12_135_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00049509"},{"key":"e_1_2_12_136_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0208145"},{"key":"e_1_2_12_137_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20201707"},{"key":"e_1_2_12_138_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40798-015-0032-x"},{"key":"e_1_2_12_139_2","article-title":"Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2\/STAT3 and Enhancing AMPK\/SIRT1 Pathways in Mice","volume":"2022","author":"Lin L.","year":"2022","journal-title":"Disease Markers"},{"key":"e_1_2_12_140_2","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2018.1526795"},{"key":"e_1_2_12_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.04.040"},{"key":"e_1_2_12_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.09.015"},{"key":"e_1_2_12_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137297"},{"key":"e_1_2_12_144_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-024-04108-w"},{"key":"e_1_2_12_145_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0618-z"},{"key":"e_1_2_12_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.02.021"},{"key":"e_1_2_12_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2023.112293"},{"key":"e_1_2_12_148_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13461"},{"key":"e_1_2_12_149_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190430"},{"key":"e_1_2_12_150_2","doi-asserted-by":"publisher","DOI":"10.12965\/jer.130071"},{"key":"e_1_2_12_151_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01233-2"},{"key":"e_1_2_12_152_2","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2020.00255","article-title":"Exercise Induces Functional and Structural Reorganization of CNS Networks in Multiple Sclerosis: A Randomized Controlled Trial","volume":"14","author":"Stellmann J. P.","year":"2020","journal-title":"Frontiers In Human Neuroscience"},{"key":"e_1_2_12_153_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-019-01025-w"},{"key":"e_1_2_12_154_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8090388"},{"key":"e_1_2_12_155_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13772"},{"key":"e_1_2_12_156_2","first-page":"276","article-title":"The Effect of Regular Treadmill Exercise on miR-10b and BDNF Expression in the Hippocampus of Female Rats","volume":"25","author":"Mohammadipour-Ghasemabad L.","year":"2018","journal-title":"Journal of Birjand University Medical Sciences"},{"key":"e_1_2_12_157_2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s12035-016-0344-y","article-title":"Voluntary Physical Exercise Induces Expression and Epigenetic Remodeling of VegfA in the Rat Hippocampus","volume":"55","author":"S\u00f8lvsten C. A. E.","year":"2018","journal-title":"Molecular Neurobiology"},{"key":"e_1_2_12_158_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-023-00154-y"},{"key":"e_1_2_12_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.01.007"},{"key":"e_1_2_12_160_2","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-023-00727-1","article-title":"Aerobic Exercise Improves Cognitive Impairment in Mice With Type 2 Diabetes by Regulating the MALAT1\/miR-382-3p\/BDNF Signaling Pathway in Serum-Exosomes","volume":"29","author":"Wang M.","year":"2023","journal-title":"Molecular Medicine"},{"key":"e_1_2_12_161_2","first-page":"368","article-title":"Impact of Exercise Training on Neuroplasticity-Related Growth Factors in Adolescents","volume":"13","author":"Pareja-Galeano H.","year":"2013","journal-title":"Journal of Musculoskeletal and Neuronal Interactions"},{"key":"e_1_2_12_162_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi6087"},{"key":"e_1_2_12_163_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0659-3"},{"key":"e_1_2_12_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.043"},{"key":"e_1_2_12_165_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2018.1562268"},{"key":"e_1_2_12_166_2","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3831972","article-title":"Exercise Modifies the Gut Microbiota With Positive Health Effects","volume":"2017","author":"Monda V.","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"e_1_2_12_167_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150502","article-title":"The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice","volume":"11","author":"Campbell S. C.","year":"2016","journal-title":"PLOS ONE"},{"key":"e_1_2_12_168_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13062099"},{"key":"e_1_2_12_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.01.017"},{"key":"e_1_2_12_170_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.07.042"},{"key":"e_1_2_12_171_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.109951","article-title":"The HPA Axis Dysregulation in Severe Mental Illness: Can We Shift the Blame to Gut Microbiota?","volume":"102","author":"Misiak B.","year":"2020","journal-title":"Progress In Neuro-Psychopharmacology & Biological Psychiatry"},{"key":"e_1_2_12_172_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.yfrne.2018.04.002","article-title":"The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective","volume":"51","author":"Cussotto S.","year":"2018","journal-title":"Frontiers in Neuroendocrinology"},{"key":"e_1_2_12_173_2","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/5127157","article-title":"The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders\u2014An Evidence Mapping Based on Quantified Evidence","volume":"2023","author":"Zang Y.","year":"2023","journal-title":"Mediators of Inflammation"},{"key":"e_1_2_12_174_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01456-3"},{"key":"e_1_2_12_175_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.2573"},{"key":"e_1_2_12_176_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.67"},{"key":"e_1_2_12_177_2","doi-asserted-by":"publisher","DOI":"10.1159\/000080655"},{"key":"e_1_2_12_178_2","doi-asserted-by":"publisher","DOI":"10.1159\/000336510"},{"key":"e_1_2_12_179_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14020232"},{"key":"e_1_2_12_180_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.2141"},{"key":"e_1_2_12_181_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1505"},{"key":"e_1_2_12_182_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2634"},{"key":"e_1_2_12_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30132-4"},{"key":"e_1_2_12_184_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpm.12101"},{"key":"e_1_2_12_185_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0404"},{"key":"e_1_2_12_186_2","doi-asserted-by":"publisher","DOI":"10.1097\/JNR.0000000000000200"},{"key":"e_1_2_12_187_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.01.038"},{"key":"e_1_2_12_188_2","doi-asserted-by":"publisher","DOI":"10.1159\/000448195"},{"key":"e_1_2_12_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2020.11.001"},{"key":"e_1_2_12_190_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.06.008"},{"key":"e_1_2_12_191_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.156"},{"key":"e_1_2_12_192_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12293"},{"key":"e_1_2_12_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00456-6"},{"key":"e_1_2_12_194_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00234.x"},{"key":"e_1_2_12_195_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.12.110"},{"key":"e_1_2_12_196_2","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1249\/mss.0b013e31802f04c7","article-title":"The Effect of Acute Exercise on Serum Brain-Derived Neurotrophic Factor Levels and Cognitive Function","volume":"39","author":"Ferris L. T.","year":"2007","journal-title":"Medicine and Science in Sports and Exercise"},{"key":"e_1_2_12_197_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181b07c4d"},{"key":"e_1_2_12_198_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.043"},{"key":"e_1_2_12_199_2","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0028-3908(98)00141-5","article-title":"Transport of Brain-Derived Neurotrophic Factor Across the Blood-Brain Barrier","volume":"37","author":"Pan W.","year":"1998","journal-title":"Neuropharmacology"},{"key":"e_1_2_12_200_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.02.007"},{"key":"e_1_2_12_201_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20979"},{"key":"e_1_2_12_202_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.07.072"},{"key":"e_1_2_12_203_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.11.014"},{"key":"e_1_2_12_204_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.09.072"},{"key":"e_1_2_12_205_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717002483"},{"key":"e_1_2_12_206_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.01.006"},{"key":"e_1_2_12_207_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-012-0261-z"},{"key":"e_1_2_12_208_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2015.10.005"},{"key":"e_1_2_12_209_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15136"},{"key":"e_1_2_12_210_2","doi-asserted-by":"publisher","DOI":"10.4081\/hpr.2019.6576"},{"key":"e_1_2_12_211_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2400"},{"key":"e_1_2_12_212_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.06.049"},{"key":"e_1_2_12_213_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1352465821000126"},{"key":"e_1_2_12_214_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2297"},{"key":"e_1_2_12_215_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2021.113449"},{"key":"e_1_2_12_216_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112084"},{"key":"e_1_2_12_217_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctcp.2022.101702","article-title":"Effects of Baduanjin Exercise on Blood Glucose, Depression and Anxiety Among Patients With Type II Diabetes and Emotional Disorders: A Meta-Analysis","volume":"50","author":"Luo X.","year":"2023","journal-title":"Complementary Therapies In Clinical Practice"},{"key":"e_1_2_12_218_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05086-4"},{"key":"e_1_2_12_219_2","doi-asserted-by":"publisher","DOI":"10.1080\/07399332.2022.2090566"},{"key":"e_1_2_12_220_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijoy.IJOY_45_19"},{"key":"e_1_2_12_221_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0816"},{"key":"e_1_2_12_222_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.05.010"},{"key":"e_1_2_12_223_2","doi-asserted-by":"publisher","DOI":"10.1177\/1078390320902825"},{"key":"e_1_2_12_224_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120578"},{"key":"e_1_2_12_225_2","doi-asserted-by":"publisher","DOI":"10.1113\/EP089501"},{"key":"e_1_2_12_226_2","unstructured":"HaysA. Effect of an Acute Bout of Aerobic Exercise on Serum Dehydroepiadosterone Sulfate (DHEAS) Levels in Clinically Diagnosed Bipolar Patients 2007 University of Pittsburgh Doctoral Dissertation."},{"key":"e_1_2_12_227_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12101280"},{"key":"e_1_2_12_228_2","first-page":"196","article-title":"The Effects of Aerobic Exercise Training on Psychosocial Aspects of Men With Type 2 Diabetes Mellitus","volume":"6","author":"Sardar M. A.","year":"2014","journal-title":"Journal of Global Health"},{"key":"e_1_2_12_229_2","first-page":"826","article-title":"Effects of Aquatic High Intensity Interval Training on Parameters of Functional Autonomy, Mental Health, and Oxidative Dysfunction in Elderly Subjects With Type 2 Diabetes","volume":"34","author":"Doyenart R.","year":"2024","journal-title":"Health Care For Women International"},{"key":"e_1_2_12_230_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13102-022-00574-3"},{"key":"e_1_2_12_231_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4161-7"},{"key":"e_1_2_12_232_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714003110"},{"key":"e_1_2_12_233_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2023.12.008"},{"key":"e_1_2_12_234_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-021-01615-5"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/da\/6651804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T15:34:51Z","timestamp":1735659291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/da\/6651804"}},"subtitle":[],"editor":[{"given":"Drozdstoy","family":"Stoyanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":234,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/da\/6651804"],"URL":"https:\/\/doi.org\/10.1155\/da\/6651804","archive":["Portico"],"relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6651804"}}