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Symptoms often begin in adolescence and are usually lifelong. Identifying shared neuroanatomical features of anxiety is essential for understanding its causes and improving treatments. Developmental abnormalities in the striatum, an obligate node in cortico\u2013striato\u2013thalamo\u2013cortical networks, could predispose to the diverse symptoms of anxiety. The striatum is comprised of two interdigitated tissue compartments, striosome and matrix, that have different embryologic origins, divergent afferent\/efferent connectivity, opposing responses to dopamine, and are embedded in distinct structural and functional networks. We used quantitative diffusion tractography to perform connectivity\u2010based parcellation, identifying striosome\u2010like and matrix\u2010like striatal voxels in a 295\u2010subject cohort (youth\u2010onset anxiety vs. matched controls). In anxiety, striosome\u2010like connectivity was depleted and dispersed, especially in a bilateral zone in the rostral putamen. Striosome\u2010like connectivity was inversely correlated with standardized assessments of anxiety. Matrix\u2010favoring connectivity was increased in a broad swath of cortico\u2010striate projections. Increases in the striatal matrix:striosome ratio may predispose individuals to anxiety.<\/jats:p>","DOI":"10.1155\/da\/7682055","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:31:04Z","timestamp":1775716264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Striosome\u2010Like Structural Connectivity Is Reduced in the Rostral Putamen in Anxiety Disorder"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4850-2539","authenticated-orcid":false,"given":"Adrian T.","family":"Funk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-1342","authenticated-orcid":false,"given":"Jeff L.","family":"Waugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4101"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.109"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.06.006"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.07.011"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213923110"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.12.015"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44322-8"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.2010.21.2.119"},{"key":"e_1_2_10_9_2","doi-asserted-by":"crossref","unstructured":"GraybielA. 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