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Depression and anxiety symptoms were assessed using the 9\u2010item Patient Health Questionnaire (PHQ\u20109) and 7\u2010item Generalized Anxiety Disorder Scale (GAD\u20107), respectively. CRP was quantified using immunoturbidimetric\u2010high\u2010sensitivity analysis. Participants were categorized by insomnia frequency (never\/rarely, sometimes, and usually). The strength symptoms and expected influence identified core symptoms, while bridge expected influence (bridge EI) determined bridge symptoms. Network comparison tests (NCTs) were performed pairwise across the three groups to assess differences in global strength and edge weights.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Across all networks, \u201cDepressed mood\u201d demonstrated the highest strength centrality, while \u201cIrritability\u201d exhibited the highest bridge EI. \u201cDepressed mood\u201d had the highest expected influence centrality in the never\/rarely insomnia group and \u201cUncontrollable worry\u201d in other groups. NCTs revealed significant differences in global strength (\n                    <jats:italic>S<\/jats:italic>\n                    \u2009=\u20090.178,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01) and edge weights (\n                    <jats:italic>M<\/jats:italic>\n                    \u2009=\u20090.062,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01) between the never\/rarely and usually insomnia groups, with stronger connections between depressive symptoms (energy\/appetite) and CRP in the usually insomnia group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The central roles of depressed mood, uncontrollable worry, and irritability in the anxiety\u2013depression\u2013CRP network across all insomnia severity groups suggest that these symptoms represent potential targets for future intervention research. Notably, network structure differed across insomnia severity; the strengthened associations between depressive symptoms and CRP in the usually insomnia group suggest that insomnia severity may be an important factor to consider in understanding the relationships between affective and inflammatory processes.\n                  <\/jats:p>","DOI":"10.1155\/da\/8836588","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:23:01Z","timestamp":1758795781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differential Anxiety\u2013Depression\u2013CRP Network Structures Across Insomnia Severity Levels: Evidence From UK 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