{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:58:37Z","timestamp":1793066317514,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":131,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20Y11902300"],"award-info":[{"award-number":["20Y11902300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the relationships between anxiety, depression, and insomnia and tinnitus severity among high\u2010functioning employed adults, stratified by age and gender, and to describe age\u2010 and gender\u2010specific patterns of prevalence and symptom burden in order to support a biopsychosocial framework for understanding tinnitus onset, progression, and clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An analysis was performed on data from 745 patients with chronic subjective tinnitus, aged 25\u201360 years, to assess levels of anxiety (HADS\u2010A), depression (HADS\u2010D), insomnia (ISI), and the perceived severity of tinnitus (THI and VAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The findings showed that anxiety was significantly correlated with the tinnitus Handicap Inventory in younger patients, particularly in men (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.611,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.001) and women (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.577,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.001) aged 25\u201340 years. In women aged 51\u201360 years, depression demonstrated the strongest association with tinnitus (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.545,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.001). In the overall cohort, insomnia exhibited a weak but statistically significant correlation with tinnitus (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009\u2264\u20090.3). Additionally, women were more likely to link tinnitus loudness to reduced quality of life, especially in the 25\u201340 (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.722,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.01) and 51\u201360 (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.689,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 &lt; 0.01) age groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings indicate that anxiety in younger patients is closely related to tinnitus, whereas depressive symptoms are more prominent among middle\u2010aged and older women. These variations indicate that patients with tinnitus may present different psychological profiles across gender and age groups. Future research may further explore the underlying pathophysiological mechanisms of tinnitus and examine its progression through long\u2010term follow\u2010up to improve understanding of its clinical heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/da\/9170627","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:40:51Z","timestamp":1778578851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Depression and Anxiety in Patients With Tinnitus: A Focus on Specific Age Groups and Sex\u2010Related 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