{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:57:17Z","timestamp":1781693837494,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":167,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Identifying core mental health symptoms is crucial for precision\u2010targeted interventions, especially in resource\u2010limited settings. However, symptom structures among individuals actively seeking telemental healthcare remain underexplored in Bangladesh and similar contexts. This study aimed to map symptom severity, factor structures, and interrelationships between depressive and anxiety symptoms to inform precision\u2010driven mental healthcare approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an observational study among 4,900 patients who attended a health facility\u2010based telemental healthcare in Bangladesh from January 2023 to July 2024. We assessed depression using PHQ\u20109 and anxiety using GAD\u20107 and applied exploratory factor analysis and network analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 84% (95% CI: 83\u201386) screened positive for depressive symptoms, 85% (95% CI: 83\u201386) screened positive for anxiety symptoms, and 77% (95% CI: 76\u201378) presented co\u2010occurring symptoms. Commonly reported symptoms included fatigue (57%), anhedonia (42%), sleep disturbance (42%), nervousness (70%), and uncontrollable worrying (66%). Factor analysis revealed \u201cdepressed mood\u201d (\u03bb\u2009=\u20090.58) and \u201canhedonia\u201d (\u03bb\u2009=\u20090.51) as core depressive features, and \u201cuncontrollable worry\u201d (\u03bb\u2009=\u20090.68) and \u201cnervousness\u201d (\u03bb\u2009=\u20090.61) as core anxiety features. Network analysis revealed strong associations between \u201canhedonia\u201d and \u201cdepressed mood\u201d in depression and \u201ctrouble relaxing\u201d and \u201crestlessness\u201d in anxiety. \u201cUncontrollable worrying\u201d showed the highest centrality, and \u201csleep disturbance\u201d and \u201ctrouble relaxing\u201d served as important bridge symptoms linking depression and anxiety domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Depressive and anxiety symptoms in people seeking telemental healthcare cluster around a small number of key and connecting symptoms, rather than contributing equally to overall distress. Precision mental healthcare in resource\u2010limited settings can use this structure to direct limited time and resources toward the symptoms that matter most.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Protocol Registration:<\/jats:bold>\n                      Institutional Review Board (IRB) of\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.icddrb.org\/\">https:\/\/www.icddrb.org\/<\/jats:ext-link>\n                      . Protocol number: PR\u201022103.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/da\/9552571","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:39:13Z","timestamp":1781692753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Network and Factor Structure of Depression and Anxiety Symptoms in Telemental Healthcare Patients From Bangladesh: Evidence for Precision Mental Healthcare"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2742-049X","authenticated-orcid":false,"given":"Md Hafizur","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3782-7859","authenticated-orcid":false,"given":"Ridwana Maher","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasimul Ghani","family":"Usmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Bony","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasnu","family":"Ara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Robed","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maruf Ahmed","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helal Uddin","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ema","family":"Akter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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