{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:37:00Z","timestamp":1784932620422,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    This study aims to explore the mutual mechanisms and distinct pathogenic factors between fasting blood glucose (FBG) abnormalities and thyroid dysfunction (TD) in major depressive disorder (MDD) patients of different onset ages.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    One thousand seven hundred eighteen first\u2010episode and drug\u2010na\u00efve (FEDN) MDD patients were selected. Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Positive and Negative Syndrome Scale (PANSS) positive subscale, Clinical Global Impression (CGI), FBG, and thyroid\u2010stimulating hormone (TSH) were measured, along with other relevant biochemical indicators.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    TD prevalence was 86.69% in early\u2010onset MDD patients with abnormal FBG while in late\u2010onset was 86.86%. No significant difference was found. The area under the curve (AUC) values of FBG detecting TD were all over 0.700. Depressive symptoms and lipid metabolites were significant risk factors and were more specific indicators for late\u2010onset MDD patients with FBG abnormalities. Further binary logistic regression and receiver operating characteristic (ROC) curves revealed that depression severity, high\u2010density lipoprotein cholesterol (HDL\u2010C) predicted TD well in MDD patients with FBG abnormalities, making this predictive effect more significant in the late\u2010onset group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Insulin resistance and lipid metabolism abnormalities based on FBG abnormalities significantly impact TD in late\u2010onset MDD. Specificity and regular monitoring should be considered for different onset ages of MDD patients with abnormal metabolism. Further research should clarify the interactions among insulin resistance, lipid metabolism, and TD. The First Hospital of Shanxi Medical University Ethics Committee reviewed and approved this study (No. 2016\u2010Y27).\n                  <\/jats:p>","DOI":"10.1155\/da\/9947375","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T22:55:21Z","timestamp":1741647321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and Pathogenic Factors of Thyroid Dysfunction in First\u2010Episode and Drug\u2010Na\u00efve Major Depressive Disorder Patients With Fasting Blood Glucose Abnormalities in Early\u2010 and Late\u2010Onset 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