{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:31:30Z","timestamp":1786609890519,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":224,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012680","name":"Universit\u00e4tsklinikum Hamburg-Eppendorf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012680","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Psoriasis lesions in the anogenital area affect about 33%\u201363% of the patients at some point in the disease course. Diminished quality of life (QoL), high depression rates, and sexual impairments have been described among patients with anogenital psoriasis, but specific treatment needs of these patients are often neglected in routine healthcare. This study aimed to compare patients with vs. without current anogenital lesions in terms of their sociodemographic and clinical characteristics, patient\u2010reported outcomes (PROs) of disease burden, and patient\u2010defined treatment needs\/benefits and to identify clinical variables associated with PROs of disease burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The study had a cross\u2010sectional case\u2013control design. Patients aged \u2265 18\u2009years with psoriasis were consecutively recruited in four German dermatology centers and were assigned to case or control group based on both patients\u2019 and physicians\u2019 reports of current anogenital involvement. PROs included the assessment of QoL impairments, treatment needs\/benefits, depression\/anxiety, perceived stigmatization, sexual frequency, and relationship\/sexual impairments. Physicians assessed the severity of psoriasis and anogenital lesions (PASI and sPGA\u2010G).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants were 294 patients with psoriasis, of which 159 (54.1%) had current anogenital lesions. Patients with anogenital lesions had higher disease severity, more comorbidities, but were less often treated with biologics. They also reported more QoL impairments, less treatment benefits, poorer mental health, and more sexual impairments. Specific treatment needs of patients with anogenital psoriasis were related to reducing physical and relationship\/sexual impairments. Poorer PROs were explained at 25%\u201368% by higher disease severity, anogenital lesions, no biologic treatment, higher intensity of itching\/burning, and lower frequency and more limitations in sexual activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within a patient\u2010centered approach to dermatology care for psoriasis, clinical decisions, particularly patients\u2019 qualification for treatment with biologic drugs, should consider not only the location, extent, and severity of psoriasis lesions but also patient\u2010reported symptoms, overall disease burden, and sexual limitations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/drp\/7159192","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:15:55Z","timestamp":1786608955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disclosing the Overall and Sex\u2010Related Disease Burden and Treatment Needs of Patients With Anogenital Psoriasis: Results From the Case\u2013Control PsoGen Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4110-9961","authenticated-orcid":false,"given":"Neuza","family":"da Silva Burger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-8728","authenticated-orcid":false,"given":"Matthias","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-7192","authenticated-orcid":false,"given":"Dagmar","family":"Wilsmann-Theis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1563-7402","authenticated-orcid":false,"given":"Athanasios","family":"Tsianakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-0284","authenticated-orcid":false,"given":"Petra","family":"Staubach-Renz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3080-497X","authenticated-orcid":false,"given":"Rachel","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0770"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0988"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1453125"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14437"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S169389"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17403"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0212-3"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0204-3"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1080-1"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16915"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000338858"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000250839"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160115"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14676"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.5655"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.040"},{"key":"e_1_2_11_19_2","first-page":"793","article-title":"The Static Physician\u2019s Global Assessment of Genitalia: A Clinical Outcome Measure for the Severity of Genital Psoriasis","volume":"16","author":"Merola J. F.","year":"2017","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0928-8"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.06.019"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.18.1.106"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.01.001"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.11.2788"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.1127"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(00)00061-1"},{"key":"e_1_2_11_27_2","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_11_28_2","doi-asserted-by":"crossref","DOI":"10.4135\/9781412983433","volume-title":"Applied Logistic Regression Analysis","author":"Menard S.","year":"2002"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235091"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17147"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17505"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_754_21"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2018.02.006"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-055477"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2020.3768"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13841"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16076"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/7006796"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.199"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/24755303231179373"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-018-0257-y"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2023.2236023"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2023.9692"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16181"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2018.09.004"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16736"}],"container-title":["Dermatology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/drp\/7159192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/drp\/7159192","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/drp\/7159192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:15:56Z","timestamp":1786608956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/drp\/7159192"}},"subtitle":[],"editor":[{"given":"Anjali","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/drp\/7159192"],"URL":"https:\/\/doi.org\/10.1155\/drp\/7159192","archive":["Portico"],"relation":{},"ISSN":["1687-6105","1687-6113"],"issn-type":[{"value":"1687-6105","type":"print"},{"value":"1687-6113","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7159192"}}