{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:06:35Z","timestamp":1784369195672,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":198,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Interleukin (IL)\u201017 and IL\u201023 inhibitors have transformed psoriasis care, delivering high clearance rates and quality\u2010of\u2010life gains. Nevertheless, inadequate response or adverse events can lead to treatment discontinuation or biologic switching. Dose modifications are also commonly implemented in routine practice to optimize efficacy, safety, and cost. The objective of this study is to characterize real\u2010world outcomes of dose adjustment and switching of IL\u201017 and IL\u201023 inhibitors in Thai patients with psoriasis. We retrospectively reviewed 173 treatment courses with IL\u201017 inhibitors (secukinumab, ixekizumab, and brodalumab) and the IL\u201023 inhibitor guselkumab, documenting loading regimens, maintenance dosing, efficacy to Week 52, and switching events. At Week 12, full loading and standard maintenance dosing were associated with higher response rates in most cases. Ixekizumab was least often given with a full loading dose or standard maintenance dosing. By Weeks 24 and 52, reduced\u2010dose regimens achieved comparable or better outcomes, suggesting careful patient selection. Thirty courses underwent biologic switching, predominantly for secondary failure. Intraclass switching among IL\u201017 inhibitors predominated. Switching from IL\u201023 to IL\u201017 inhibitors potentially outperformed both intraclass IL\u201017 switching or IL\u201017\u2010to\u2010IL\u201023 transitions. Erythrodermic psoriasis and higher baseline disease severity predicted switching, whereas incomplete loading doses and dose reductions did not. In conclusion, full loading and standard maintenance regimens facilitate early treatment response, while dose reduction in carefully selected patients can sustain long\u2010term disease control without increasing the risk of switching.<\/jats:p>","DOI":"10.1155\/drp\/7998583","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:48:46Z","timestamp":1784368126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Dose Adjustment and Switching of Interleukin\u201017\/23 Inhibitors for Thai Psoriasis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-5206","authenticated-orcid":false,"given":"Chayada","family":"Chaiyabutr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teerapat","family":"Paringkarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanakorn","family":"Woramongkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-1365","authenticated-orcid":false,"given":"Thrit","family":"Hutachoke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-5442","authenticated-orcid":false,"given":"Narumol","family":"Silpa-Archa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-6445","authenticated-orcid":false,"given":"Leena","family":"Chularojanamontri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-3229","authenticated-orcid":false,"given":"Chanisada","family":"Wongpraparut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1590"},{"key":"e_1_2_10_2_2","first-page":"202","article-title":"IL-23 Versus IL-17 in the Pathogenesis of Psoriasis: There is More to the Story Than IL-17A","volume":"18","author":"Armstrong A.","year":"2019","journal-title":"Journal of Drugs in Dermatology: Journal of Drugs in Dermatology"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.026"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.12932\/AP-240425-2072"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2024.103287"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16915"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_10_8_2","article-title":"Systemic Pharmacological Treatments for Chronic Plaque Psoriasis: A Network Meta-Analysis","volume":"7","author":"Sbidian E.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.70062"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llaf250"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15686"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00559-z"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2200870"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20739"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/btt.s252578"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.057"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00693-2"},{"key":"e_1_2_10_18_2","article-title":"Thai Universal Coverage Scheme: Toward a More Stable System","volume":"3","author":"Narin J.","year":"2017","journal-title":"Social Science Asia"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1369805"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16915"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2089328"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2200869"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15067"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2021.1937187"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13860"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.25259\/ijdvl_308_2022"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14834"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-024-01257-2"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.17465"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18381"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15772"}],"container-title":["Dermatology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/drp\/7998583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/drp\/7998583","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/drp\/7998583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:48:48Z","timestamp":1784368128000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/drp\/7998583"}},"subtitle":[],"editor":[{"given":"Anjali","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/drp\/7998583"],"URL":"https:\/\/doi.org\/10.1155\/drp\/7998583","archive":["Portico"],"relation":{},"ISSN":["1687-6105","1687-6113"],"issn-type":[{"value":"1687-6105","type":"print"},{"value":"1687-6113","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7998583"}}