{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:38:27Z","timestamp":1762954707199},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA65053-O1R"],"award-info":[{"award-number":["CA65053-O1R"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic and Therapeutic Endoscopy"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>In recent years endoscopically controlled laser\u2010induced thermal therapy (LITT) has been\nincreasingly accepted as a minimally invasive method for palliation of advanced or recurrent\nhead and neck or gastrointestinal cancer. Previous studies have shown that adjuvant\nchemotherapy can potentiate endoscopic laser thermal ablation of obstructing tumors leading\nto improved palliation in advanced cancer patients. Eight patients with recurrent head and\nneck tumors volunteered to enroll as part of an ongoing phase II LITT clinical trial, and also\nelected to be treated with systemic chemotherapy (cisplatin, 80 mg\/m<jats:sup>2<\/jats:sup>) followed 24 h later by\npalliative laser thermal ablation. Laser treatments were repeated in patients with residual\ndisease or recurrence for a total of 27 LITT sessions. Four of the 8 patients treated with laser\nthermal chemotherapy remained alive after a median follow\u2010up of 12 months. Of the 12 tumor\nsites treated, complete responses were located in the oral cavity (3), oropharynx (1),\nhypopharynx (1), maxillary sinus (1), and median survival for these patients was 9.5 months.\nThis initial experience with cisplatinum\u2010based laser chemotherapy indicates both safety and\ntherapeutic potential for palliation of advanced head and neck cancer but this must be confirmed\nby longer follow\u2010up in a larger cohort of patients.<\/jats:p>","DOI":"10.1155\/dte.6.133","type":"journal-article","created":{"date-parts":[[2007,8,30]],"date-time":"2007-08-30T12:42:21Z","timestamp":1188477741000},"page":"133-140","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combined Cisplatinum and Laser Thermal Therapy for Palliation of Recurrent Head and Neck Tumors"],"prefix":"10.1155","volume":"6","author":[{"given":"Marcos B.","family":"Paiva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romaine E.","family":"Saxton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith E.","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Buechler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alen","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carson D.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Calcaterra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan J.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,11,17]]},"container-title":["Diagnostic and Therapeutic Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2000\/413725.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/DTE.6.133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:33:46Z","timestamp":1723070026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/DTE.6.133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,17]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/DTE.6.133"],"URL":"https:\/\/doi.org\/10.1155\/dte.6.133","archive":["Portico"],"relation":{},"ISSN":["1070-3608","1029-0516"],"issn-type":[{"type":"print","value":"1070-3608"},{"type":"electronic","value":"1029-0516"}],"subject":[],"published":{"date-parts":[[1999,11,17]]},"assertion":[{"value":"1999-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-11-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}