{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:47:49Z","timestamp":1791074869650,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>A new spontaneously diabetic strain of the Sprague\u2010Dawley rat was established in 1997 and named\nthe SDT (Spontaneously Diabetic Torii) rat. In this\nresearch, we investigated the characteristics of the\ndisease condition in the SDT rats. The time of onset\nof glucosuria was different between male and\nfemale SDT rats; glucosuria appeared at approximately\n20 weeks of age in male rats and at approximately\n45 weeks of age in female rats. A cumulative\nincidence of diabetes of 100% was noted by 40\nweeks of age in male rats, while it was only 33.3%\neven by 65 weeks of age in female rats. The survival\nrate up to 65 weeks of age was 92.9% in male\nrats and 97.4% in female rats. Glucose intolerance\nwas observed in male rats from 16 weeks of age.\nThe clinical characteristics of the male SDT rats\nwere (1) hyperglycemia and hypoinsulinemia (from\n25 weeks of age); (2) long\u2010term survival without insulin\ntreatment; (3) hypertriglyceridemia (by 35\nweeks of age); however, no obesity was noted in\nany of the male rats. The histopathological characteristics\nof the male rats with diabetes mellitus\n(DM) were (1) fibrosis of the pancreatic islets (by\n25 weeks of age); (2) cataract (by 40 weeks of age);\n(3) tractional retinal detachment with fibrous proliferation\n(by 70 weeks of age) and (4) massive hemorrhaging\nin the anterior chamber (by 77 weeks of age).\nThese clinical and histopathological characteristics\nof the disease in SDT rats resemble those of human\nType 2 diabetes with insulin hyposecretion. In conclusion,\nSDT rat is considered to be a potentially\nuseful model for studies of diabetic retinopathy\nencountered in humans.<\/jats:p>","DOI":"10.1155\/edr.2000.89","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T12:14:15Z","timestamp":1173269655000},"page":"89-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["A New Spontaneously Diabetic Non\u2010obese Torii Rat Strain With Severe Ocular Complications"],"prefix":"10.1155","volume":"1","author":[{"given":"Masami","family":"Shinohara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Masuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Shoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadakazu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Katsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajuro","family":"Komeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Kuroki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Kakehashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Kanazaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1999,12,30]]},"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2000\/371689.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/EDR.2000.89","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T03:13:58Z","timestamp":1723086838000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/EDR.2000.89"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12,30]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/EDR.2000.89"],"URL":"https:\/\/doi.org\/10.1155\/edr.2000.89","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12,30]]},"assertion":[{"value":"1999-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}