{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:45:55Z","timestamp":1761947155826,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":152,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>We investigated the changes in GH\u2010IGF\u2010I axis in\nnon\u2010obese diabetic (NOD)\u2010mice, a model of insulin dependent\ndiabetes mellitus. Diabetic female NOD\nmice and their age\u2010 and sex\u2010matched controls were\nsacrificed at 4, 14, 21 and 30 days (30d DM) after the\nonset of glycosuria. Serum GH levels increased and\nserum IGF\u2010I levels decreased in the 30d DM group\n(182 \u00b1 32% and 45 \u00b1 24% of age\u2010matched controls\nrespectively, p &lt; 0.05). Another group (30d DM + I)\nwas given SC insulin, and its serum IGF\u2010I levels\nremained decreased. Liver GH receptor (GHR) and\nGH binding protein (GHBP) mRNA levels, as well\nas liver membrane GH binding assays were deeply\ndecreased in the 30d DM group in comparison to\ncontrols. GHR message and binding capacity remained\ndecreased in the 30d DM + I group. Renal\nGHR mRNA was decreased at 21d DM but not at\n14d DM, whereas GHBP mRNA remained unchanged\nthroughout the experiment. In conclusion,\nincreased serum GH levels are documented in NOD\ndiabetic mice, similarly to the changes described in\nhumans. The decrease in GHR levels and decreased\nserum IGF\u2010I in spite of increased circulating GH\nsuggest a state of GH resistance.<\/jats:p>","DOI":"10.1155\/edr.2000.9","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T12:14:15Z","timestamp":1173269655000},"page":"9-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Changes in the Growth Hormone\u2010IGF\u2010I Axis in Non\u2010obese Diabetic Mice"],"prefix":"10.1155","volume":"1","author":[{"given":"Daniel","family":"Landau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Segev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Eshet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Flyvbjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Phillip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,8,2]]},"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2000\/528169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/EDR.2000.9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:16:29Z","timestamp":1723076189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/EDR.2000.9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/EDR.2000.9"],"URL":"https:\/\/doi.org\/10.1155\/edr.2000.9","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"type":"print","value":"2314-6745"},{"type":"electronic","value":"2314-6753"}],"subject":[],"published":{"date-parts":[[1999,8,2]]},"assertion":[{"value":"1999-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}