{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:02:15Z","timestamp":1723075335836},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>Plasma levels of glucose, insulin and glucagon were\nmeasured at various time intervals after pancreatic\nduct ligation (PDL) in rabbits. Two hyperglycemic\nperiods were observed: one between 15\u201390 days\n(peak at 30 days of 15.1 \u00b1 1.2mmol\/l, p &lt; 0.01), and\nthe other at 450 days (11.2 \u00b1 0.5 mmol\/l, p &lt; 0.02). The\nfirst hyperglycemic episode was significantly correlated\nwith both hypoinsulinemia (41.8 \u00b1 8pmol\/l,\nr= \u20130.94, p &lt; 0.01) and hyperglucagonemia (232 \u00b1 \n21ng\/l, r=0.95, p &lt; 0.01). However, the late hyperglycemic\nphase (450 days), which was not accompanied\nby hypoinsulinemia, was observed after the\nhyperglucagonemia (390 days) produced by abundant\nimmunostained A\u2010cells giving rise to a 3\u2010fold\nincrease in pancreatic glucagon stores. The insulin\nand glucagon responses to glucose loading at 180,\n270 and 450 days reflected the insensitivity of B\u2010 and\nA\u2010cells to glucose. The PDL rabbit model with\nchronic and severe glycemic disorders due to the\npredominant role of glucagon mimicked key features\nof the NIDDM syndrome secondary to\nexocrine disease.<\/jats:p>","DOI":"10.1155\/edr.2001.101","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T12:14:33Z","timestamp":1173269673000},"page":"101-112","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insulin and Glucagon Impairments in Relation with Islet Cells Morphological Modifications Following Long Term Pancreatic Duct Ligation in the Rabbit \u2013 A Model of Non\u2010insulin\u2010dependent Diabete"],"prefix":"10.1155","volume":"2","author":[{"given":"J.","family":"Catala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Daumas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Pham Huu","family":"Chanh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lasserre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Hollande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,2,21]]},"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2001\/243204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/EDR.2001.101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T20:14:11Z","timestamp":1723061651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/EDR.2001.101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1155\/EDR.2001.101"],"URL":"https:\/\/doi.org\/10.1155\/edr.2001.101","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"type":"print","value":"2314-6745"},{"type":"electronic","value":"2314-6753"}],"subject":[],"published":{"date-parts":[[2001,1]]},"assertion":[{"value":"2000-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-02-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}