{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:26:24Z","timestamp":1790277984614,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Department of Health and Personal Social Services"},{"name":"Northern Ireland and University of Ulster Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>Esters of succinic acid are potent insulin secretagogues,\nand have been proposed as novel antidiabetic\nagents for type 2 diabetes. This study\nexamines the effects of acute and chronic exposure\nto succinic acid monomethyl ester (SAM) on insulin\nsecretion, glucose metabolism and pancreatic beta\ncell function using the BRIN\u2010BD11 cell line. SAM\nstimulated insulin release in a dose\u2010dependent\nmanner at both non\u2010stimulatory (1.1mM) and stimulatory\n(16.7mM) glucose. The depolarizing actions\nof arginine also stimulated a significant increase\nin SAM\u2010induced insulin release but 2\u2010ketoisocaproic\nacid (KIC) inhibited SAM induced insulin\nsecretion indicating a possible competition between\nthe preferential oxidative metabolism of these two\nagents. Prolonged (18hour) exposure to SAM revealed\ndecreases in the insulin\u2010secretory responses\nto glucose, KIC, glyceraldehyde and alanine.\nFurthermore, SAM diminished the effects of nonmetabolized\nsecretagogues arginine and 3\u2010isobutyl\u20101\u2010methylxanthine (IBMX). While the ability of\nBRIN\u2010BD11 cells to oxidise glucose was unaffected\nby SAM culture, glucose utilization was substantially\nreduced. Collectively, these data suggest that\nwhile SAM may enhance the secretory potential of\nnon\u2010metabolized secretagogues, it may also serve as\na preferential metabolic fuel in preference to other\nimportant physiological nutrients and compromise\npancreatic beta cell function following prolonged\nexposure.<\/jats:p>","DOI":"10.1155\/edr.2001.19","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T12:14:33Z","timestamp":1173269673000},"page":"19-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Differential Acute and Long Term Actions of Succinic Acid Monomethyl Ester Exposure on Insulin\u2010Secreting BRIN\u2010BD11 Cells"],"prefix":"10.1155","volume":"2","author":[{"given":"Sally F.","family":"Picton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Flatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville H.","family":"McClenaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2000,10]]},"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2001\/724079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/EDR.2001.19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T20:30:56Z","timestamp":1723062656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/EDR.2001.19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1155\/EDR.2001.19"],"URL":"https:\/\/doi.org\/10.1155\/edr.2001.19","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]},"assertion":[{"value":"2000-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}