{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T04:10:02Z","timestamp":1723090202508},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["4582"],"award-info":[{"award-number":["4582"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>The present study was designed to examine the development\nof hypertension in diabetic rats treated\nwith streptozotocin (STZ, 1mg\/g bw). The rats were\nstudied at 3, 6, 9, 12 and 15 weeks. From the third\nweek the rats were divided in diabetic rats according\ntheir glycemias and controls, along 15 weeks. After\nthe third week a group, of rats showed increased urinary\nprotein excretion (93, 134, 155 and 191%) compared\nto controls. In this group of rats the urinary\nkallikrein excretion was lower than control and the\nsystolic blood pressure became significantly elevated\nbetween 3 and 6 weeks and persisted up to 15 weeks.\nOn the other hand a group of diabetic rats were normotensive\nwith urinary protein excretion similar to\ncontrols and urinary kallikrein lower compared to\ncontrol but significantly higher compared diabetic\nhypertensive rats. These data suggest that the association\nof progressive diabetic nephropathy with abnormal\nendothelium\u2010dependent vasodilation may\nproduce a high prevalence of hypertensive diabetes.<\/jats:p>","DOI":"10.1155\/edr.2001.195","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T12:14:33Z","timestamp":1173269673000},"page":"195-199","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Diabetic Nephropathy and the Development of Hypertension in Rats"],"prefix":"10.1155","volume":"2","author":[{"given":"Adriana","family":"Zuccollo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Catanzaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,6,25]]},"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2001\/909250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/EDR.2001.195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T03:32:17Z","timestamp":1723087937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/EDR.2001.195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1155\/EDR.2001.195"],"URL":"https:\/\/doi.org\/10.1155\/edr.2001.195","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"type":"print","value":"2314-6745"},{"type":"electronic","value":"2314-6753"}],"subject":[],"published":{"date-parts":[[2001,1]]},"assertion":[{"value":"2001-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}